D1 but not D2 dopamine receptor antagonism blocks the acquisition of a flavor preference conditioned by intragastric carbohydrate infusions
D1 but not D2 dopamine receptor antagonism blocks the acquisition of a flavor preference conditioned by intragastric carbohydrate infusions
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DOI：
10.1016/s0091-3057(01)00484-1
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发表时间：
2001-04-01
影响因子：
3.6
通讯作者：
Sclafani, A
中科院分区：
文献类型：
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作者：
Azzara, AV;Bodnar, RJ;Sclafani, A
研究了多巴胺D-1 （SCH23390）和D-2 （raclopride）受体拮抗剂对蔗糖摄食后条件下风味偏好获得和表达的影响。限制食物的大鼠在一瓶训练中，将一种调味糖精溶液（CS+）与灌胃（ig） 16%蔗糖相关联，另一种调味糖精溶液（CS-）与水相关联。然后在两瓶测试中测量口味偏好。在实验1A中，在整个训练过程中，接受D-2拮抗剂（raclopride, 200 nmol/kg； RAC组）的大鼠消耗的CS+和CS-比盐水处理的对照组大鼠少；盐处理组的摄入量限制在RAC组。在两瓶试验中，所有三组在用生理盐水或氯氯pride治疗时均表现出CS+偏好，除非剂量极大地抑制了摄入。实验1B在整个训练过程中给药400 nmol/kg的大鼠也得到了类似的结果。在实验2中，在训练过程中给予DI拮抗剂（SCH23390, 200 nmol/kg； SCH组）的大鼠比盐水处理的对照组大鼠消耗的CS+和CS-少；盐处理的Yoked组的摄入量限制在SCH组。与对照组和对照组不同，在两次瓶子测试中，SCH组没有更喜欢CS+而不是CS-。在两瓶试验期间，除了剂量极大地抑制摄入外，对照组或轭组的SCH23390治疗并未阻断CS+偏好。我们得出结论，多巴胺受体D-1，而不是D-2，在获得蔗糖条件下的风味偏好中起关键作用，并且这两种受体亚型在这种偏好的表达中都有更有限的作用。(C) 2001爱思唯尔科学公司版权所有。
The effects of dopamine D-1 (SCH23390) and D-2 (raclopride) receptor antagonists on the acquisition and expressions of flavor preferences conditioned by the postingestive actions of sucrose were investigated. Food-restricted rats were trained in one-bottle sessions to associate one flavored saccharin solution (CS+) with intragastric (ig) infusions of 16% sucrose, and another flavored saccharin solution (CS-) with water infusions. Flavor preferences were then measured in two-bottle tests. In Experiment 1A, rats that received the D-2 antagonist (raclopride, 200 nmol/kg; RAC group) throughout training consumed less CS+ and CS- than did saline-treated Control rats; a saline-treated Yoked group had its intake limited to that of the RAC group. All three groups displayed CS+ preferences during two-bottle tests when treated with saline or raclopride, except at doses that greatly suppressed intake. Experiment 1B obtained similar results with rats treated with 400 nmol/kg raclopride throughout training. In Experiment 2, rats that received the DI antagonist (SCH23390, 200 nmol/kg; SCH group) throughout training consumed less CS+ and CS- than did saline-treated Control rats; a saline-treated Yoked group had its intake limited to that of the SCH group. Unlike the Control and Yoked groups, the SCH group failed to prefer the CS+ to the CS- in two bottle tests. SCH23390 treatment during two-bottle testing did not block CS+ preference in the Control or Yoked groups, except at doses that greatly suppressed intake. We conclude that D-1, but not D-2, dopamine receptors are critically involved in the acquisition of a sucrose-conditioned flavor preference, and both receptor subtypes have a more limited role in the expression of this preference. (C) 2001 Elsevier Science Inc. All rights reserved.