Bone mineral density and bone markers in patients with a recent low-energy fracture: effect of 1 y of treatment with calcium and vitamin D
Bone mineral density and bone markers in patients with a recent low-energy fracture: effect of 1 y of treatment with calcium and vitamin D
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DOI：
10.1093/ajcn/86.1.251
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发表时间：
2007-07-01
影响因子：
7.1
通讯作者：
Eskildsen, Peter C.
中科院分区：
文献类型：
--
作者：
Hitz, Mette F.;Jensen, Jens-Erik B.;Eskildsen, Peter C.
背景资料：髋部、前臂、肩部和脊柱的低能量骨折是骨质疏松症的已知后果。目的：我们评估了钙和维生素D治疗1年对近期低能量骨折患者骨密度（BMD）和骨标志物的影响。设计：在双盲设计中，髋关节骨折患者（下肢骨折，或LEF）或上肢（UEF）被随机分配接受3000 mg碳酸钙+ 1400 IU胆钙化醇或安慰剂（200 IU胆钙化醇）。采用双能X线骨密度仪测量髋关节和腰椎骨密度，采用定时Up & Go试验评估体能。血清中25-羟基胆钙化醇，甲状旁腺激素（PTH），telepeptide的I型胶原（ICTP），骨钙素，和N-末端前肽的I型胶原bearingmeasured.Results：共122例患者（84%的妇女;（x）超过酒吧+/- SD年龄：70 +/- 11年）; 68%完成了研究。在意向性治疗分析中，干预组LBMD增加，安慰剂组LBMD减少，12个月后两组差异显著：0.931 +/- 0.211与0.848 +/- 0.194（P < 0.05）。HBMD无显著变化。治疗效果在年龄较大的患者中更为明显
Background: Low-energy fractures of the hip, forearm, shoulder, and spine are known consequences of osteoporosis.Objective: We evaluated the effect of 1 y of treatment with calcium and vitamin D on bone mineral density (BMD) and bone markers in patients with a recent low-energy fracture.Design: In a double-blinded design, patients with fracture of the hip (lower-extremity fracture, or LEF) or upper extremity (UEF) were randomly assigned to receive 3000 mg calcium carbonate + 1400 IU cholecalciferol or placebo (200 IU cholecalciferol). BMD of the hip (HBMD) and lumbar spine (LBMD) were evaluated by dual-energy X-ray absorptiometry, and physical performance was assessed by the timed Up & Go test. Serum concentrations of 25-hydroxycholecalciferol, parathyroid hormone (PTH), telepeptide of type I collagen (ICTP), osteocalcin, and N-terminal propeptide of collagen type I were measured.Results: A total of 122 patients were included (84% women; (x) over bar +/- SD age: 70 +/- 11 y); 68% completed the study. In an intention-to-treat analysis, LBMD increased in the intervention group and decreased in the placebo group, and the difference between the groups was significant after 12 mo: 0.931 +/- 0.211 compared with 0.848 +/- 0.194 (P < 0.05). No significant change was shown for HBMD. The effect of treatment was more pronounced in patients aged