Synchronization of Midbrain Dopaminergic Neurons Is Enhanced by Rewarding Events
Synchronization of Midbrain Dopaminergic Neurons Is Enhanced by Rewarding Events
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DOI：
10.1016/j.neuron.2009.04.026
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发表时间：
2009-06-11
期刊：
影响因子：
16.2
通讯作者：
Bergman, Hagai
中科院分区：
文献类型：
--
作者：
Joshua, Mati;Adler, Avital;Bergman, Hagai
基底神经节网络分为两个功能相关的子系统：神经调节器和主轴。假设神经调节剂调节皮质纹状体耦合。这种调整可能取决于神经调节剂之间的反应特性和时间相互作用。我们研究了当猴子执行包括奖励、中性和厌恶事件在内的经典条件反射任务时，同时记录的基底神经节神经元对之间的功能相互作用。属于单个神经调节剂组的神经元表现出相似的平均反应，而主轴神经元以高度多样化的方式做出反应。在奖励而非厌恶事件后，多巴胺能神经调节剂短暂地增加了试验与试验（噪音）的相关性，而纹状体的胆碱能神经元则降低了试验与试验的相关性。这些功能连接的变化发生在试验的不同时期。因此，神经调节器（但不是主轴神经元）的编码方案可以被视为通过动态神经元相互作用进一步丰富的单维代码。
The basal ganglia network is divided into two functionally related subsystems: the neuromodulators and the main axis. It is assumed that neuromodulators adjust cortico-striatal coupling. This adjustment might depend on the response properties and temporal interactions between neuromodulators. We studied functional interactions between simultaneously recorded pairs of neurons in the basal ganglia while monkeys performed a classical conditioning task that included rewarding, neutral, and aversive events. Neurons that belong to a single neuromodulator group exhibited similar average responses, whereas main axis neurons responded in a highly diverse manner. Dopaminergic neuromodulators transiently increased trial-to-trial (noise) correlation following rewarding but not aversive events, whereas cholinergic neurons of the striatum decreased their trial-to-trial correlation. These changes in functional connectivity occurred at different epochs of the trial. Thus, the coding scheme of neuromodulators (but not main axis neurons) can be viewed as a single-dimensional code that is further enriched by dynamic neuronal interactions.