Molecularly based analysis of deformation of spectrin network and human erythrocyte
Molecularly based analysis of deformation of spectrin network and human erythrocyte
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DOI：
10.1016/j.msec.2005.08.020
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发表时间：
2006-09-01
期刊：
影响因子：
--
通讯作者：
Suresh, S.
中科院分区：
文献类型：
--
作者：
Dao, M.;Li, J.;Suresh, S.
我们研究的大变形弹性响应的血影蛋白网络在人红细胞（RBC）的基础上的分子水平的本构关系。这些配方被证明是一致的连续水平的RBC的超弹性变形模型的预测，并与最近的实验研究，使用光镊拉伸的全细胞变形进行比较。这些分析提取细胞膜和细胞骨架的响应，从全细胞计算模拟的大变形的RBC血影蛋白网络的现实几何形状的影响。大变形的方面，如折叠的细胞壁在大变形过程中，也进行了检查。我们还提供了一般的标度关系和封闭形式的功能的基础上，可以从光镊实验中提取的红细胞的机械性能。(c)2005 Elsevier B.V.保留所有权利。
We examine the large deformation elastic response of the spectrin network in a human red blood cell (RBC) on the basis of molecular-level constitutive laws. These formulations are shown to be consistent with the predictions of continuum level models for the hyperelastic deformation of RBC, and are compared with recent experimental studies of whole-cell deformation using optical tweezers stretching. Implications of these analysis for extracting cell membrane and cytoskeleton response from whole-cell computational simulations of large deformation for realistic geometries of RBC spectrin network are described. Aspects of large deformation, such as the folding of cell wall during large deformation, are also examined. We also provide general scaling relationships and closed-form functions on the basis of which mechanical properties of RBCs can be extracted from optical tweezers experiments. (c) 2005 Elsevier B.V. All rights reserved.