Nanomaterials targeting macrophages in sepsis: A promising approach for sepsis management.
Nanomaterials targeting macrophages in sepsis: A promising approach for sepsis management.
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DOI：
10.3389/fimmu.2022.1026173
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
脓毒症是由宿主对感染的反应失调引起的危及生命的器官功能障碍。巨噬细胞在机体抵抗病原体和脓毒症的免疫发病机制中发挥重要作用，如吞噬病原体、分泌细胞因子和表型重编程等。然而，脓毒症的快速进展损害巨噬细胞功能，并且常规的抗微生物和支持性治疗不足以恢复失调的巨噬细胞作用。纳米粒子具有独特的物理化学性质、表面功能、局部表面等离子体共振现象、体内被动靶向性、良好的生物相容性和生物可降解性等特点，在生物医学领域具有广泛的应用前景。一旦进入体内，NPs就被宿主免疫系统识别。巨噬细胞是先天免疫中的吞噬细胞，专门用于识别外来物质，包括纳米颗粒，随后发生免疫应答。各种设计策略，如表面功能化，已被实施来操纵单核细胞/巨噬细胞识别纳米颗粒，并被它们吞噬以调节它们在脓毒症中的功能，弥补脓毒症传统方法的缺点。本文综述了纳米材料靶向巨噬细胞的作用机制以及脓毒症中靶向巨噬细胞的纳米药物的研究进展，为探索脓毒症中基于巨噬细胞的纳米治疗提供了有益的参考。
Sepsis is a life-threatening organ dysfunction resulting from dysregulated host responses to infection. Macrophages play significant roles in host against pathogens and the immunopathogenesis of sepsis, such as phagocytosis of pathogens, secretion of cytokines, and phenotype reprogramming. However, the rapid progression of sepsis impairs macrophage function, and conventional antimicrobial and supportive treatment are not sufficient to restore dysregulated macrophages roles. Nanoparticles own unique physicochemical properties, surface functions, localized surface plasmon resonance phenomenon, passive targeting in vivo, good biocompatibility and biodegradability, are accessible for biomedical applications. Once into the body, NPs are recognized by host immune system. Macrophages are phagocytes in innate immunity dedicated to the recognition of foreign substances, including nanoparticles, with which an immune response subsequently occurs. Various design strategies, such as surface functionalization, have been implemented to manipulate the recognition of nanoparticles by monocytes/macrophages, and engulfed by them to regulate their function in sepsis, compensating for the shortcomings of sepsis traditional methods. The review summarizes the mechanism of nanomaterials targeting macrophages and recent advances in nanomedicine targeting macrophages in sepsis, which provides good insight for exploring macrophage-based nano-management in sepsis.
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影响因子：
120.7
作者：
Boomer, Jonathan S.;To, Kathleen;Chang, Kathy C.;Takasu, Osamu;Osborne, Dale F.;Walton, Andrew H.;Bricker, Traci L.;Jarman, Stephen D., II;Kreisel, Daniel;Krupnick, Alexander S.;Srivastava, Anil;Swanson, Paul E.;Green, Jonathan M.;Hotchkiss, Richard S.
通讯作者：
Hotchkiss, Richard S.
影响因子：
6.7
作者：
Chiu, Hui-Wen;Xia, Tian;Wang, Ying-Jan
通讯作者：
Wang, Ying-Jan
DOI：
10.1016/j.msec.2017.11.014
发表时间：
2018-02-01
影响因子：
7.9
作者：
Chen, Guoqiang;Xu, Yunfei
通讯作者：
Xu, Yunfei
影响因子：
5
作者：
Beyeler, Seraina;Steiner, Selina;Blank, Fabian
通讯作者：
Blank, Fabian
DOI：
10.1073/pnas.78.9.5275
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-PHYSICAL SCIENCES
影响因子：
--
作者：
DREXLER, KE
通讯作者：
DREXLER, KE