Young women, body size and risk of atrial fibrillation
Young women, body size and risk of atrial fibrillation
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DOI：
10.1177/2047487317740644
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发表时间：
2018-01-01
影响因子：
8.3
通讯作者：
Rosengren, Annika
中科院分区：
文献类型：
--
作者：
Persson, Christina E.;Adiels, Martin;Rosengren, Annika
背景成年早期体型较大与男性晚年发生房颤的风险增加有关；然而，在女性中尚未对此进行研究。设计：前瞻性队列研究。方法：我们纳入了1982年至2014年瑞典医学出生登记处中所有已知体重和身高的女性。主暴露体表面积(BSA)以(身高[cm]×体重[kg]/3600)的平方根计算。有关房颤的医院诊断信息从患者登记处获得。研究人群包括1,522,329名女性(平均年龄28.3岁)。结果：在最长33.6年(平均16.6年，可信区间为16.6-16.6)的随访期内，共有6993名妇女(0.5%)被诊断为房颤。房颤的风险随着BSA、身体质量指数(BMI)和身高的增加而线性上升，在最大的女性中，风险增加了三倍。与第一个四分位数比较，与BSA相关的危险比分别为1.21(95%可信区间1.12~1.30)、1.45(95%可信区间1.35~1.56)和2.11(95%可信区间1.97~2.26)。在对不同的BMI水平进行分层后，即使在BMI正常的低水平的女性中，风险的增加仍然存在。结论成年早期测量的较大体型独立于BMI，与女性在长达33年的随访中发生房颤的风险增加相关。
Background A large body size in early adult life has been associated with an increased risk of atrial fibrillation (AF) later in life in men; however, this has not yet been investigated in women. Design: Prospective cohort study. Methods: We included all women in the Swedish Medical Birth Registry with known weight and height from 1982 to 2014. The main exposure body surface area (BSA) was calculated as the square root of (height [cm] x weight [kg]/3600). Information on hospital diagnoses of AF were obtained from the Patient Registry. The study population comprised 1,522,329 women (mean age 28.3 years). Results: A total of 6993 women (0.5%) were diagnosed with AF during a maximum follow-up of 33.6 years (mean 16.6 years, confidence interval [CI] 16.6-16.6). Risk of AF rose linearly with increasing BSA, body mass index (BMI) and height, with up to a threefold increased risk in the biggest women. Hazard ratios associated with BSA were 1.21 (95% CI 1.12-1.30), 1.45 (95% CI 1.35-1.56) and 2.11 (95% CI 1.97-2.26) when comparing the second, third and fourth quartiles, respectively, with the first. The elevated risk persisted after stratifying for different levels of BMI, even among women with low-normal BMI.Conclusion A larger body size measured early in adulthood was, independent from BMI, associated with an increased risk of AF in women during follow-up of up to 33 years.