Effect of vitamin E isoforms on the primary intention skin wound healing of diabetic rats.
Effect of vitamin E isoforms on the primary intention skin wound healing of diabetic rats.
复制标题
DOI：
10.7241/ourd.20174.108
复制
发表时间：
2017-01-01
期刊：
影响因子：
--
通讯作者：
Maheshwari, V.
中科院分区：
文献类型：
--
作者：
Bijo Elsy, Bijo Elsy;Khan, A. A.;Maheshwari, V.
前言：创面愈合受损事件是糖尿病的常见并发症。维生素E是一种对皮肤伤口愈合有效的营养抗氧化剂，它含有饱和生育酚和不饱和生育三烯酚。本研究旨在探讨不同维生素E亚型对健康和糖尿病大鼠皮肤缝合创面的影响。材料和方法：48只大鼠随机分为8组：健康对照组、糖尿病对照组、健康组(d-α-生育酚、d-Delta-TRF联合给药)和糖尿病组(d-α-生育酚、d-Delta-TRF联合给药)。单次皮下注射100 mg/kg四氧嘧啶诱导糖尿病模型。治疗组予d-α-生育酚(200 mg/kg)、d-Delta-TRF(200 mg/kg)及两者合用(各100 mg/kg)，每日1次，连续3周。在右侧大腿中段水平切开皮肤，长2.950.17 cm，用可吸收缝线缝合伤口。结果：3周末组织病理学和组织形态学结果显示，d-Delta-TRF治疗组比d-α-生育酚组和联合用药组更有效地促进原发创面表皮和真皮成分的再生和重组。结论：在不同的维生素E亚型中，d-Delta-TRF对健康人和糖尿病患者的皮肤创面愈合均是一种更有效的营养抗氧化剂。
Introduction: Impaired wound healing events is a common complication in diabetes. One of the effective nutritional antioxidant on skin wound healing is vitamin E which contains saturated tocopherol and unsaturated tocotrienol forms. This present study is designed to explore the effect of different vitamin E isoforms on stitched skin wound in both healthy and diabetic rats. Materials and Methods: Forty eight albino rats were divided into eight groups; healthy control, diabetic control, healthy treated (d-alpha-tocopherol, d-delta-TRF and co-administrated) and diabetic treated (d-alpha-tocopherol, d-delta-TRF and co-administrated). Diabetes was induced through single subcutaneous injection of alloxan at the dose of 100 mg/kg. Treated groups were administered d-a-tocopherol (200 mg/kg), d-delta-TRF (200 mg/kg) and co-administration (100 mg/kg of these two compounds each) orally and daily for three weeks. A horizontal skin incision was made on right mid-thigh region at 2.950.17 cm in length and wound was closed with an absorbable suture. Results: Histopathological and histomorphological results at the end of 3rd week revealed that the d-delta-TRF treated groups promote the regeneration and reorganization of epidermal and dermal components in healing of primary intention more effectively than the d-alpha-tocopherol and co-administrated groups. Conclusion: It is concluded that among different vitamin E isoforms the d-delta-TRF appears to be a more effective nutritional antioxidant on skin wound healing in both healthy and diabetics.