Antigen 85A and mycobacterial DNA-binding protein 1 are targets of immunoglobulin G in individuals with past tuberculosis
Antigen 85A and mycobacterial DNA-binding protein 1 are targets of immunoglobulin G in individuals with past tuberculosis
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DOI：
10.1111/j.1348-0421.2012.12005.x
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发表时间：
2013-01-01
影响因子：
2.6
通讯作者：
Matsumoto, Sohkichi
中科院分区：
文献类型：
--
作者：
Osada-Oka, Mayuko;Tateishi, Yoshitaka;Matsumoto, Sohkichi
人们认为，开发准确的方法从潜伏状态预测结核病的进展，对于控制结核病至关重要，因为大多数病例是由潜伏感染发展而来。与以前接受过治疗的潜伏结核分枝杆菌感染患者相比，从未接受过治疗的既往结核病患者进展的风险更高。对未接受药物治疗的结核病患者的23种结核分枝杆菌蛋白抗体反应进行了评估。这些个体的抗原85A和分枝杆菌dna结合蛋白1 （MDP1）抗体浓度明显高于活动性结核患者和未感染对照。此外，免疫组化在无症状患者的结核性肉芽肿病变中发现结核杆菌、抗原85和MDP1共定位，表明病变中结核分枝杆菌同时表达抗原85和MDP1。我们的研究表明，测量抗体对抗原85A和MDP1的反应对于评估结核病进展的风险可能有用。
Development of accurate methods for predicting progression of tuberculosis (TB) from the latent state is recognized as vitally important in controlling TB, because a majority of cases develop from latent infections. Past TB that has never been treated has a higher risk of progressing than does latent Mycobacterium tuberculosis infection in patients who have previously received treatment. Antibody responses against 23 kinds of M. tuberculosis proteins in individuals with past TB who had not been medicated were evaluated. These individuals had significantly higher concentrations of antibodies against Antigen 85A and mycobacterial DNA-binding protein 1 (MDP1) than did those with active TB and uninfected controls. In addition, immunohistochemistry revealed colocalization of tubercle bacilli, antigen 85 and MDP1 inside tuberculous granuloma lesions in an asymptomatic subject, showing that M. tuberculosis in lesions expresses both antigen 85 and MDP1. Our study suggests the potential usefulness of measuring antibody responses to antigen 85A and MDP1 for assessing the risk of TB progression.