Longitudinal study of the diffusion tensor imaging properties of the corpus callosum in acute and chronic diffuse axonal injury
Longitudinal study of the diffusion tensor imaging properties of the corpus callosum in acute and chronic diffuse axonal injury
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DOI：
10.3109/02699052.2011.558038
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发表时间：
2011-04-01
期刊：
影响因子：
1.9
通讯作者：
Skoglund, Thomas
中科院分区：
文献类型：
--
作者：
Ljungqvist, Johan;Nilsson, Daniel;Skoglund, Thomas
背景资料：磁共振弥散张量成像（MR-DTI）越来越多地用于检测创伤性脑损伤（TBI）后弥漫性轴索损伤（DAI）。主要目的：主要目的是调查急性期和TBI后6个月胼胝体弥散特性的变化，并检查DTI参数与临床结果之间的相关性。研究设计：纵向前瞻性研究：方法和步骤：对8名疑似DAI的患者在伤后11天内和6个月内进行了MR-DTI检查。还检查了6个对照组。分析胼胝体的各向异性分数（FA）、迹线、平行和垂直扩散率。主要结果是扩展的格拉斯哥结局量表评分，在6 months.Main结局和结果进行评估：与健康对照组相比，在急性期患者的胼胝体FA显着减少。平行或垂直特征值或迹线无显著变化。在6个月，FA显着减少和显着增加的痕迹和垂直的特征值，注意到与controls.Conclusions相比：胼胝体的扩散特性与临床结果在这个纵向调查。
Background: Magnetic resonance diffusion tensor imaging (MR-DTI) is used increasingly to detect diffuse axonal injury (DAI) after traumatic brain injury (TBI).Primary objective: The primary objective was to investigate the changes in the diffusion properties of the corpus callosum in the acute phase and 6 months after TBI and to examine the correlation between DTI parameters and clinical outcome.Research design: Longitudinal prospective study.Methods and procedures: MR-DTI was performed in eight patients with suspected DAI within 11 days and at 6 months post-injury. Six controls were also examined. Fractional anisotropy (FA), trace and parallel and perpendicular diffusivity of the corpus callosum were analysed. The main outcome was the extended Glasgow Outcome Scale score, assessed at 6 months.Main outcomes and results: A significant reduction in FA in the corpus callosum was seen in the acute phase in patients compared with the healthy controls. There was no significant change in the parallel or perpendicular eigenvalues or trace. At 6 months, a significant reduction in FA and a significant increase in trace and perpendicular eigenvalues were noticed compared with controls.Conclusions: The diffusion properties of the corpus callosum correlated with clinical outcome in this longitudinal investigation.