Adrenarche: a survey of rodents, domestic animals, and primates.
Adrenarche: a survey of rodents, domestic animals, and primates.
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肾上腺初现：对啮齿动物、家畜和灵长类动物的调查。
作者：
G. Cutler;Michael Glenn;M. Bush;G. Hodgen;C. Graham;D. Loriaux
肾上腺类固醇脱氢表雄酮（DHA），硫酸脱氢表雄酮（DHAS）和δ 4-雄烯二酮的浓度（δ 4-A）在啮齿类动物、家养动物和灵长类动物，以确定这些物种是否表现出与人类相似的肾上腺素分泌过程。DHA和DHAS的平均浓度分别低于60 ng/dl和5微克/dl。dl，并且仅在兔和狗中观察到性成熟后血浆DHA水平显着增加。21只0-3岁恒河猴的DHA、DHAS和δ 4-A浓度分别为2021 +/- 235 ng/dl（平均值+/- SE）、357 +/- 60微克/dl和107 +/- 9 ng/dl，在性成熟过程中没有增加。相比之下，7- 22岁黑猩猩血浆中的DHA、DHAS和δ 4-A水平分别是0- 3岁黑猩猩的5.9倍、3.3倍和4.8倍。从时间上看，黑猩猩DHA水平的增加在5岁时是明显的，这先于性腺类固醇的增加，这是人类肾上腺初显的特征。很明显，肾上腺雄激素水平及其发育模式在物种之间存在显著差异，在所研究的物种中，只有黑猩猩表现出与人类相当的肾上腺初显。
The concentrations of the adrenal steroids dehydroepiandrosterone (DHA), dehydroepiandrosterone sulfate (DHAS), and delta 4-androstenedione (delta 4-A) have been measured by RIA before and after sexual maturation in plasma of rodents, domestic animals, and primates to determine whether these species exhibit and adrenarchal process comparable to man. The average concentrations of DHA and DHAS were less than 60 ng/dl and 5 microgram/dl, respectively, in plasma of sexually mature rodents and domestic animals, and a significant increase in the plasma DHA level after sexual maturation was seen only in the rabbit and dog. The concentrations of DHA, DHAS, and delta 4-A in 21 rhesus monekeys from 0-3 yr of age were 2021 +/- 235 ng/dl (mean +/- SE), 357 +/- 60 microgram/dl, and 107 +/- 9 ng/dl, respectively, and did not increase during sexual maturation. By contrast, DHA, DHAS, and delta 4-A levels in plasma of chimpanzees were 5.9-fold, 3.3-fold, and 4.8-fold greater, respectively, in 7- to 22-compared to 0- to 3-yr-old animals. Temporally, the increase in DHA levels in the chimpanzee is apparent at 5 yr and this precedes the increase in gonadal steroids, as is characteristic of human adrenarche. It is apparent that adrenal androgen levels and their developmental patterns differ markedly among species, and that among the species examined, only the chimpanzee exhibits an adrenarche comparable to that of man.