Dietary restriction in pregnant rats causes gender-related hypertension and vascular dysfunction in offspring
Dietary restriction in pregnant rats causes gender-related hypertension and vascular dysfunction in offspring
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DOI：
10.1111/j.1469-7793.2001.0141m.x
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发表时间：
2001-01-01
影响因子：
5.5
通讯作者：
Poston, L
中科院分区：
文献类型：
--
作者：
Ozaki, T;Nishina, H;Poston, L
1. 我们研究了大鼠妊娠期间中度整体营养不良对雄性和雌性后代血压以及全身血管功能发育的影响。怀孕Wistar大鼠在妊娠0至18天期间进行营养限制（R），喂养正常妊娠匹配膳食摄入量的70%。2． R 后代出生时生长迟缓，但 20 天时体重与对照 (C) 相似。通过股动脉导管直接测量的收缩压和/或舒张压和平均动脉压，从 60 天起，雄性 R 后代中升高（平均动脉压：第 60 天，P < 0.01；第 100 天，P < 0.05；第 200 天，P < 0.005，R vs. C），雌性 R 后代中从 100 天起（平均动脉压：第 100 天和第 200 天的动脉压，P < 0.05；R 与 C).3。第 20 天幼犬的离体股动脉对去氧肾上腺素 (PE) (P < 0.05) 和去甲肾上腺素 (NA) (P < 0.05) 的最大收缩减少。这些差异并没有持续到成年。在雄性成年R后代（200天）中，对血栓素A（2）模拟物U46619（P < 0.05）的最大血管收缩和对钾的敏感性（P < 0.01）增强。4．大鼠妊娠期母亲中度营养不良会对后代的心血管功能产生不利影响。这些异常随着年龄的增长而增加，并且在男性中更为明显。
1. We have investigated the effects of moderate global undernutrition during gestation in the rat on the blood pressure of male and female offspring, and on the development of systemic vascular function. Pregnant Wistar rats were nutritionally restricted (R) by feeding with 70% of the normal gestation-matched dietary intake from 0 to 18 days gestation.2. R offspring were growth retarded at birth but of similar weight to controls (C) at 20 days. Systolic and/or diastolic and mean arterial blood pressures, measured directly by femoral artery catheter, were elevated from 60 days onward in male R offspring (mean arterial pressure: day 60, P < 0.01; day 100, P < 0.05; day 200, P < 0.005, R vs. C), and from 100 days onward in female R offspring (mean arterial pressure day 100 and day 200, P < 0.05; R vs. C).3. Maximal constriction to phenylephrine (PE) (P < 0.05) and to noradrenaline (NA) (P < 0.05) was reduced in isolated femoral arteries of day 20 R pups. These differences did not persist into adulthood. In male adult R offspring (200 days), maximal vasoconstriction to the thromboxane A(2) mimetic, U46619 (P < 0.05) and sensitivity to potassium (P < 0.01) were enhanced.4. Moderate maternal undernutrition in rat gestation adversely affects cardiovascular function in the offspring. These abnormalities increase with age and are more pronounced in males.