Altered expression of DACH1 and cyclin D1 in endometrial cancer
Altered expression of DACH1 and cyclin D1 in endometrial cancer
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DOI：
10.4161/cbt.8.16.8963
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发表时间：
2009-08-15
影响因子：
3.6
通讯作者：
Wang, Chenguang
中科院分区：
文献类型：
--
作者：
Nan, Fangfang;Lue, Qingtao;Wang, Chenguang
人DACH 1（Drosophila Dachshund同源物）表达的改变与肿瘤进展和转移相关。DACH 1通过细胞周期蛋白D1抑制乳腺癌细胞增殖。子宫内膜癌是女性中第三常见的癌症，广泛筛查DACH 1表达将进一步加深我们对这种疾病的了解。在此，我们筛选了126例子宫切除术标本的DACH 1表达，并评估了DACH 1水平与几个临床参数之间的相关性。DACH 1表达降低与FIGO手术分期（I-II期与III-IV期，p = 0.017）、腹膜细胞学（p = 0.044）、淋巴结阳性（p = 0.035）和组织学类型（p = 0.007）显著相关，但与组织学分级、子宫肌层深度和患者年龄无关。免疫组化法检测细胞周期蛋白D1、雌激素受体α（ER α）和孕激素受体（PR）的表达。采用逐步考克斯比例风险模型进行多因素分析，结果显示FIGO手术分期、组织学分级、淋巴结转移和PR表达与生存率相关。尽管单变量分析表明DACH 1阳性与所有患者的5年生存率增加相关（p = 0.037），但DACH 1表达减少作为预测子宫内膜癌生存率的独立预后因素并没有显着价值。我们的研究结果表明，DACH 1表达的丢失可能参与子宫内膜癌的进展。
The altered expression of human DACH1, a Drosophila Dachshund homolog, has been associated with tumor progression and metastasis. DACH1 inhibits breast cancer cellular proliferation via cyclin D1. Endometrial cancer is the third most common cancer in women and broad screening for DACH1 expression will further our understanding of this disease. Herein, we screened 126 hysterectomy specimens for DACH1 expression and evaluated the correlation between DACH1 levels and several clinical parameters. Decreased DACH1 expression was significantly correlated with FIGO surgical stages (Stage I-II vs. stage III-IV, p = 0.017), peritoneal cytology (p = 0.044), lymph node positivity (p = 0.035) and histological type (p = 0.007), but not histological grade, depth of myometrial and patient age. Immunostaining was also conducted to examine the expression of cyclin D1, estrogen receptor alpha (ER alpha) and progesterone receptor (PR) in these specimens. Multivariate analysis using the stepwise Cox proportional hazard model showed that FIGO surgical stage, histological grade, lymph node metastasis, and PR expression were correlated with poor survival. Despite the fact that univariate analysis demonstrated that DACH1 positivity is associated with increased 5-year survival in all patients (p = 0.037), decreased expression of DACH1 had no significant value as an independent prognostic factor in predicting survival in endometrial cancers. Our results suggested that loss of DACH1 expression might be involved in endometrial cancer progression.