Long-term outcome in patients with apical hypertrophic cardiomyopathy
Long-term outcome in patients with apical hypertrophic cardiomyopathy
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DOI：
10.1016/s0735-1097(01)01778-8
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发表时间：
2002-02-20
影响因子：
24
通讯作者：
Rakowski, H
中科院分区：
文献类型：
--
作者：
Eriksson, MJ;Sonnenberg, B;Rakowski, H
目的：本研究的目的是描述心尖肥厚型心肌病(ApHCM)患者在第三转诊中心接受治疗后的长期预后。方法对1975年至2000年在多伦多总医院确诊的105例ApHCM患者进行了回顾性研究。分析患者的症状、临床表现、病死率和心血管并发症。结果平均发病年龄41.4±14.5岁。在平均13.6+/-8.3年的随访期间，心血管死亡率为1.9%(2/105)，年心血管死亡率为0.1%。15年的总存活率为95%。32例患者(30%)有一个或多个主要致病事件，最常见的是心房颤动(12%)和心肌梗死(10%)。15年时无病态事件的生存概率为74%。确定了心血管发病率的三个预测因素：发病时的年龄
OBJECTIVES The aim of this study was to describe long-term outcome in patients with apical hypertrophic cardiomyopathy (ApHCM) followed in a tertiary referral center.BACKGROUND Apical hypertrophic cardiomyopathy is a relatively rare form of hypertrophic cardiomyopathy (HCM), first described in Japan. Initial reports, based on a limited number of patients, emphasized the benign nature of this condition.METHODS A retrospective study of 105 patients with ApHCM diagnosed at the Toronto General Hospital from 1975 to 2000 was performed. Symptoms, clinical findings, mortality and cardiovascular morbidity were analyzed.RESULTS The mean age at presentation was 41.4 +/- 14.5 years. During a mean follow-up of 13.6 +/- 8.3 years from presentation, cardiovascular mortality was 1.9% (2/105) and annual cardiovascular mortality was 0.1%. Overall survival was 95% at 15 years. Thirty-two patients (30%) had one or more major morbid events, the most frequent being atrial fibrillation (12%) and myocardial infarction (10%). Probability of survival without morbid events was 74% at 15 years. Three predictors of cardiovascular morbidity were identified: age at presentation