Dose-dependent immune response to Mycobacterium bovis BCG vaccination in neonates
Dose-dependent immune response to Mycobacterium bovis BCG vaccination in neonates
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DOI：
10.1128/cvi.00309-06
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发表时间：
2007-02-01
影响因子：
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通讯作者：
Kaplan, Gilla
中科院分区：
文献类型：
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作者：
Davids, Virginia;Hanekom, Willem;Kaplan, Gilla
在出生时接种日本牛分枝杆菌卡介苗的10周龄婴儿中，卡介苗刺激6天后，真皮穿刺量与全血中CD4(+)T细胞的增殖频率呈正相关，而与7天后分泌的细胞因子水平及卡介苗刺激12小时后干扰素的CD4(+)T细胞频率无相关性。
In 10-week-old infants vaccinated at birth with Japanese Mycobacterium bovis BCG, the number of dermal needle penetrations correlated positively with frequency of proliferating CD4(+) T cells in whole blood following BCG stimulation for 6 days but did not correlate with secreted cytokine levels after 7 It or interferon CD4(+) T-cell frequency after 12 h of BCG stimulation.