The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development.
The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development.
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DOI：
10.1006/scdb.2001.0288
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发表时间：
2002-02
影响因子：
7.3
通讯作者：
N. Ward;D. Dumont
中科院分区：
文献类型：
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作者：
N. Ward;D. Dumont
通过新芽生长、间质生长或肠套叠生长对原有血管进行扩张或重建，称为血管生成，是一个高度调控的过程。血管生成不仅在正常胚胎血管发育中至关重要，而且在包括癌症、牛皮癣和糖尿病在内的几种疾病的进展中也是至关重要的。小鼠分子遗传学实验表明，血管生成素及其受体Tie2/Tek对于胚胎血管发育是不可或缺的。血管生成素信号通路的重要性也已被证明超越发育，延伸到体外和体内血管生成生长的实验模型。目前，血管生成素的确切作用尚不清楚。然而，从遗传、异种移植、组织化学和细胞培养实验中发现，内皮细胞对血管生成素的反应似乎是背景和内皮细胞类型特异性的。
The expansion or remodelling of pre-existing blood vessels, known as angiogenesis, by either nascent sprouting, intercalated or intussusceptive growth is a highly regulated process. Angiogenesis is critical not only during normal embryonic vascular development, but also in the progression of several diseases, including cancer, psoriasis, and diabetes. Mouse molecular genetic experiments have shown that the angiopoietins and their receptor Tie2/Tek are indispensable for embryonic vessel development. The importance of the angiopoietin-signalling pathway has also been shown to extend beyond development, into in vitro and in vivo experimental models of angiogenic growth. Currently the precise role of the angiopoietins remains unclear. However, what is emerging from genetic, xenograft transplant, histochemical and cell culture experiments are that the response of endothelial cells to angiopoietins appears to be context and endothelial cell type specific.