Antibiotic Use and Type 1 Diabetes in Childhood
Antibiotic Use and Type 1 Diabetes in Childhood
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DOI：
10.1093/aje/kwp038
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发表时间：
2009-05-01
影响因子：
5
通讯作者：
Svanstrom, Henrik
中科院分区：
文献类型：
--
作者：
Hviid, Anders;Svanstrom, Henrik
越来越多的间接证据表明抗生素的使用（尤其是在儿童早期）与长期免疫健康之间存在关联。作者评估了儿童时期使用抗生素与随后发展为 1 型糖尿病之间的关联。对 1995 年至 2003 年期间出生的所有丹麦单胎儿童（n = 606,420）进行了一项全国性队列研究。根据抗生素使用情况，估计了儿童 1 型糖尿病的发病率比率。抗生素的使用根据类别、使用次数和使用年龄进行分类。使用任何抗生素均与 1 型糖尿病无关（比率 = 1.16，95% 置信区间：0.91、1.50）。根据任何抗生素疗程数对 1 型糖尿病风险进行评估，发现抗生素使用与 1 型糖尿病之间没有关联，每个疗程的比率增加了 1.02（95% 置信区间：0.97、1.07）。没有特定类别的抗生素与 1 型糖尿病相关，没有特定的使用年龄与 1 型糖尿病相关，也没有特定的 1 型糖尿病发病年龄与抗生素相关。在一项大型全国性前瞻性研究中，未发现丹麦儿童使用抗生素与 1 型糖尿病之间存在关联。
Indirect evidence is accumulating for an association between antibiotic use, especially in early childhood, and long-term immunologic health. The authors evaluated the association between antibiotic use in childhood and subsequent development of type 1 diabetes. A nationwide cohort study of all Danish singleton children born during 1995-2003 (n = 606,420) was conducted. Incidence rate ratios for type 1 diabetes comparing children according to antibiotic use were estimated. Antibiotic use was classified according to class, number of uses, and age at use. Use of any antibiotic was not associated with type 1 diabetes (rate ratio = 1.16, 95% confidence interval: 0.91, 1.50). Evaluation of type 1 diabetes risk according to number of courses of any antibiotic yielded no association between antibiotic use and type 1 diabetes, with an increase in rate ratio per course of 1.02 (95% confidence interval: 0.97, 1.07). No specific class of antibiotics was associated with type 1 diabetes, no specific age of use was associated with type 1 diabetes, and no specific age at onset of type 1 diabetes was associated with antibiotics. In a large nationwide prospective study, no association between antibiotic use and type 1 diabetes was found among Danish children.