FMRI responses to cold pressor challenges in control and obstructive sleep apnea subjects
FMRI responses to cold pressor challenges in control and obstructive sleep apnea subjects
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DOI：
10.1152/japplphysiol.00881.2002
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发表时间：
2003-04-01
影响因子：
3.3
通讯作者：
Yan-Go, FL
中科院分区：
文献类型：
--
作者：
Harper, RM;Macey, PM;Yan-Go, FL
阻塞性睡眠呼吸暂停（OSA）患者表现出交感神经流出的改变，这可能揭示了该综合征的潜在机制。我们使用功能性MRI（fMRI）在16名对照组和10名OSA受试者谁是免费的心血管或改变情绪的药物，以检查神经反应的前额冷加压挑战，这elenerate呼吸减慢，心动过缓，增强交感神经流出。冷诱发心动过缓的幅度较小，呼吸减慢显示出更大的受试者间变异性，并在OSA患者中达到最低点。两组在多个大脑部位对冷刺激显示出相似的信号变化。然而，信号增加出现在OSA的前，后扣带回，小脑和额叶皮质的控制，而信号显着下降，而在腹侧丘脑，海马和海马，而不是上升的控制。异常反应通常会导致呼吸和心率的变化。延髓、中脑和豆状核。OSA患者小脑齿状核也呈低信号。冷加压生理反应在OSA中被改变，并且可能由多个脑结构中的减弱和夸大的反应引起。
Obstructive sleep apnea (OSA) patients exhibit altered sympathetic outflow, which may reveal mechanisms underlying the syndrome. We used functional MRI (fMRI) in 16 control and 10 OSA subjects who were free of cardiovascular or mood-altering drugs to examine neural responses to a forehead cold pressor challenge, which elicits respiratory slowing, bradycardia, and enhanced sympathetic outflow. The magnitude of cold-induced bradycardia was smaller, and respiratory slowing showed greater intersubject variability and reached a nadir later in OSA patients. Both groups showed similar signal changes to cold stimulation in multiple brain sites. However, signal increases emerged in OSA over controls in anterior and posterior cingulate and cerebellar and frontal cortex, whereas signals markedly declined in the ventral thalamus, hippocampus, and insula rather than rising as in controls. Anomalous responses often paralleled changes in breathing and heart rate. Medullary, midbrain areas and lentiform. and cerebellar dentate nuclei also showed lower signals in OSA cases. Cold pressor physiological responses are modified in OSA and may result from both diminished and exaggerated responses in multiple brain structures.