A NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPIC AND CONFORMATIONAL STUDY OF 8 PSEUDO-TREHALOSES (D-GLUCOPYRANOSYL 5A-CARBA-D-GLUCOPYRANOSIDES AND (D-GLUCOPYRANOSYL-5A-CARBA-L-GLUCOPYRANOSIDES)
A NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPIC AND CONFORMATIONAL STUDY OF 8 PSEUDO-TREHALOSES (D-GLUCOPYRANOSYL 5A-CARBA-D-GLUCOPYRANOSIDES AND (D-GLUCOPYRANOSYL-5A-CARBA-L-GLUCOPYRANOSIDES)
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DOI：
10.1016/0008-6215(91)80144-c
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发表时间：
1991-01-15
影响因子：
3.1
通讯作者：
YOKOI, S
中科院分区：
文献类型：
--
作者：
BOCK, K;GUZMAN, JF;YOKOI, S
N.m.r.给出了8种假海藻糖衍生物的数据（H-1和C-13），其中D-吡喃葡萄糖基部分是α或β，5 α-吡喃葡萄糖苷部分是α-D、β-D、α-L或β-L。化学位移和n.O.e.的影响已经与从经验力场计算（HSEA），已被用来计算整个能量表面的平均参数估计的优选构象。在四种α-D-吡喃葡萄糖基衍生物中，只有具有5 α-卡巴-β-D-吡喃葡萄糖苷部分的衍生物（3）是葡糖淀粉酶的底物。
N.m.r. data (H-1 and C-13) are presented for eight pseudo-trehalose derivatives in which the D-glucopyranosyl moiety is alpha or beta and the 5a-carbaglucopyranoside moiety is alpha-D, beta-D, alpha-L, or beta-L. The differences in the chemical shifts and the n.O.e. effects have been correlated with the preferred conformations estimated from empirical force-field calculations (HSEA), which have been used to calculate the average parameters over the whole energy surface. Of the four alpha-D-glucopyranosyl derivatives, only that with a 5a-carba-beta-D-glucopyranoside moiety (3) was a substrate for glucoamylase.