Birth weight is nongenetically associated with glucose intolerance in elderly twins, independent of adult obesity
Birth weight is nongenetically associated with glucose intolerance in elderly twins, independent of adult obesity
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DOI：
10.1111/j.1365-2796.2007.01793.x
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发表时间：
2007-07-01
影响因子：
11.1
通讯作者：
Poulsen, P.
中科院分区：
文献类型：
--
作者：
Grunnet, L.;Vielwerth, S.;Poulsen, P.
目标。使用一种独特的双胞胎方法，我们检查了出生体重由遗传和非遗传因素决定的程度，以及出生体重和葡萄糖代谢指标之间的关联是源于遗传还是源于非遗传。采用口服葡萄糖耐量试验(OGTT)对已知出生体重的138对55~73岁同性同卵双生子(MZ)和214对异卵双生子(DZ)进行了口服葡萄糖耐量试验(OGTT)。确定出生体重的遗传度，并进行回归分析，采用双胞胎内出生体重差异和葡萄糖代谢指标，并对成人肥胖进行调整和不调整。出生体重的遗传度估计为38%。我们发现MZ双胞胎的出生体重与血糖稳态指标之间存在显著的非遗传关联，出生体重每增加1公斤，空腹血糖、OGTT后120分钟血糖、空腹血浆胰岛素和HOMA-IR指数分别下降15.7%、25.5%、26.4%和37.2%。出生体重和糖耐量之间的非遗传负关联与成人肥胖无关，而出生体重和胰岛素抵抗之间的非遗传关联仍然存在，尽管在调整了当前的身体尺寸后没有那么强烈。我们证明了老年双胞胎出生体重的基因成分。当调整这种影响时，我们发现出生体重和葡萄糖耐量以及胰岛素抵抗之间存在非遗传的负相关，这种关联部分独立于成人肥胖。这意味着胎儿环境会影响老年双胞胎的血糖稳态。
Objectives. Using a unique twin approach, we examined the extent to which birth weight is determined by genetic and nongenetic factors and whether associations between birth weight and measures of glucose metabolism are of genetic or nongenetic origin.Setting/subjects. An oral glucose tolerance test (OGTT) was performed in a population-based cohort of twins including 138 same-sex monozygotic (MZ) and 214 dizygotic (DZ) twin pairs aged 55-73 years whose birth weight was known. Heritability of birth weight was determined and regression analyses with intra-twin pair differences of birth weight and measures of glucose metabolism, with and without adjustment for adult obesity, were performed.Results. The heritability of birth weight was estimated to be 38%. We demonstrated significant nongenetic associations between birth weight and measures of glucose homeostasis in MZ twins, with a reduction in fasting plasma glucose, 120 min post-OGTT plasma glucose, fasting plasma insulin and HOMA-IR index of 15.7%, 25.5%, 26.4% and 37.2%, respectively, for every 1 kg increase in birth weight. The nongenetic negative associations between birth weight and measures of glucose intolerance were independent of adult obesity, whereas the nongenetic association between birth weight and insulin resistance persisted, although not as strongly, after adjusting for current body size.Conclusions. We demonstrated a genetic component to birth weight in elderly twins. When adjusting for this influence, we found a nongenetic negative association between birth weight and glucose tolerance as well as insulin resistance that was partially independent of adult obesity. This implies that the foetal environment influences glucose homeostasis in elderly twins.