Localized actions of progesterone in hypothalamus involve oxytocin.
Localized actions of progesterone in hypothalamus involve oxytocin.
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黄体酮在下丘脑的局部作用涉及催产素。
DOI：
10.1073/pnas.86.17.6798
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发表时间：
1989
影响因子：
11.1
通讯作者：
McEwen,BS
中科院分区：
文献类型：
--
作者：
Schumacher,M;Coirini,H;Frankfurt,M;McEwen,BS
两种卵巢激素雌二醇和孕酮通过作用于下丘脑腹内侧核（VMN）促进雌性大鼠的交配行为，诱导该脑区催产素受体结合的变化。雌激素诱导VMN和周围区域的催产素受体结合增加4倍，并增加腹侧VMN外侧区域的催产素纤维的数量和免疫染色。在雌激素刺激的大鼠中，孕酮导致诱导的催产素受体遍布含有催产素纤维的区域。催产素注入腹内侧下丘脑增加了前凸行为的显示，只有在女性与苯甲酸雌二醇和孕酮启动。因此，两种卵巢激素的顺序作用使神经肽及其受体登记，并使神经肽发挥行为效应。
Two ovarian hormones, estradiol and progesterone, which facilitate mating behavior in the female rat by acting on the ventromedial nuclei (VMN) of the hypothalamus, induce changes in oxytocin receptor binding in this brain region. Estradiol induced a 4-fold increase in the oxytocin receptor binding of the VMN and surrounding area and increased the number and immunostaining of oxytocin fibers in an area lateral to the ventral VMN. Progesterone, in estrogen-primed rats, caused the induced oxytocin receptors to spread over the area containing the oxytocin fibers. Infusion of oxytocin into the ventromedial hypothalamus increased the display of lordosis behavior only in females primed with both estradiol benzoate and progesterone. Thus, the sequential actions of two ovarian hormones bring a neuropeptide and its receptors into register and enable the neuropeptide to exert behavioral effects.