Chemokine Regulation of Neutrophil Infiltration of Skin Wounds.
Chemokine Regulation of Neutrophil Infiltration of Skin Wounds.
复制标题
DOI：
10.1089/wound.2014.0559
复制
发表时间：
2014-08
影响因子：
4.9
通讯作者：
Yingjun Su;A. Richmond
中科院分区：
文献类型：
--
作者：
Yingjun Su;A. Richmond
意义：中性粒细胞有效募集到损伤的皮肤病变是伤口修复的重要先天免疫应答。中性粒细胞募集缺陷导致伤口愈合受损。最新进展：已知趋化因子和趋化因子受体调节中性粒细胞募集。最近的研究进展揭示了更多关于趋化因子和趋化因子受体对中性粒细胞从骨髓中排出、迁移到伤口部位、向坏死皮肤组织的空间导航以及通过红细胞增多症诱导的清除的调节机制细节。关键问题：皮肤损伤引发多种趋化分子表达的局部和全身改变以及趋化因子受体介导的信号传导的幅度。许多CXC和CX3C趋化因子及其受体的反应与炎症期中性粒细胞向伤口部位的时间和空间募集密切相关，并在向增殖期过渡期间促进坏死中性粒细胞的清除。这些趋化因子和趋化因子受体系统的功能异常被认为是伤口愈合受损的病理学基础的重要机制之一。未来发展方向：未来的研究应致力于通过靶向炎症早期特异性趋化因子或趋化因子受体来研究中性粒细胞活性的治疗调节，以改善伤口愈合的临床管理。
Significance: Efficient recruitment of neutrophils to an injured skin lesion is an important innate immune response for wound repair. Defects in neutrophil recruitment lead to impaired wound healing. Recent Advances: Chemokines and chemokine receptors are known to regulate neutrophil recruitment. Recent research advances reveal more mechanistic details about the regulation of chemokines and chemokine receptors on neutrophil egress from bone marrow, transmigration into the wound site, spatial navigation toward the necrotic skin tissue, and apoptosis-induced clearance by efferocytosis. Critical Issues: Skin injury triggers local and systemic alterations in the expression of multiple chemotactic molecules and the magnitude of chemokine receptor-mediated signaling. The responses of a number of CXC and CX3C chemokines and their receptors closely associate with the temporal and spatial recruitment of neutrophils to wound sites during the inflammatory phase and promote the clearance of necrotic neutrophils during the transition into the proliferative phase. Functional aberrancy in these chemokines and chemokine receptor systems is recognized as one of the important mechanisms underlying the pathology of impaired wound healing. Future Directions: Future research should aim to investigate the therapeutic modulation of neutrophil activity through the targeting of specific chemokines or chemokine receptors in the early inflammatory phase to improve clinical management of wound healing.