Particle size and drug interactions of injectable corticosteroids used in ophthalmic practice
Particle size and drug interactions of injectable corticosteroids used in ophthalmic practice
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DOI：
10.1016/s0161-6420(96)30411-9
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发表时间：
1996-11-01
期刊：
影响因子：
13.7
通讯作者：
Haik, BG
中科院分区：
文献类型：
--
作者：
Francis, BA;Chang, EL;Haik, BG
目的：本研究的目的是比较市售的皮质类固醇的病灶内注射的制造商的规格，并评估与其他类固醇和其他常用solutions.Methods混合时的大小变化：地塞米松磷酸钠，醋酸甲泼尼龙，曲安奈德，和倍他米松磷酸钠和倍他米松醋酸酯的颗粒大小进行了测量与库尔特计数器。每种类固醇与每一个其他的，利多卡因，利多卡因与肾上腺素混合，然后立即测量，并在1小时后，以确定对颗粒大小的影响。当地塞米松与利多卡因单独混合时，立即和1小时后，地塞米松显示出颗粒数增加。曲安西龙仅在与利多卡因单独混合后1小时显示出粒度增加。当与利多卡因和肾上腺素混合时，曲安西龙、地塞米松和甲泼尼龙颗粒的尺寸会增加。地塞米松和曲安西龙与利多卡因和肾上腺素混合后，当允许静坐1小时时，显示出尺寸的额外增加。混合类固醇引起的颗粒大小没有增加。结论：由于在一个解决方案中的颗粒大于20 μ m的数量增加也增加了血管闭塞的可能性，作者敦促在这些药物的混合，特别是利多卡因和肾上腺素的护理。如果需要混合，作者建议随后立即进行注射。
Purpose: The aim of this study is to compare the particle sizes of commercially available corticosteroids for intralesional injection to manufacturers' specifications and to evaluate changes in size when mixed with other steroids and other commonly used solutions.Methods: The particle sizes of dexamethasone sodium phosphate, methylprednisolone acetate, triamcinolone acetonide, and betamethasone sodium phosphate and betamethasone acetate were measured with the Coulter counter. Each steroid was mixed with each of the others, lidocaine, and lidocaine with epinephrine, then measured immediately and after 1 hour to determine the effect on particle size.Results: All steroids showed accurate manufacturer specifications. Dexamethasone showed an increase in particle sire when mixed with lidocaine alone, immediately and after 1 hour. Triamcinolone showed an increase in particle size only after 1 hour after mixture with lidocaine alone. Triamcinolone, dexamethasone, and methylprednisolone particles increased in size when mixed with lidocaine and epinephrine. Dexamethasone and triamcinolone showed an additional increase in size when allowed to sit for 1 hour after mixture with lidocaine and epinephrine. Mixing steroids caused no increase in particle size.Conclusions: Because an increase in the number of particles greater than 20 mu m in a solution also increases the likelihood of vascular occlusion, the authors urge care in the mixing of these drugs, especially with lidocaine and epinephrine. if mixture is necessary, the authors recommend that injection take place immediately subsequent.