Leisure-Time and Non-Leisure-Time Physical Activities are Dose-Dependently Associated With a Reduced Risk of Dementia in Community-Dwelling People Aged 40-74 Years: The Murakami Cohort Study
Leisure-Time and Non-Leisure-Time Physical Activities are Dose-Dependently Associated With a Reduced Risk of Dementia in Community-Dwelling People Aged 40-74 Years: The Murakami Cohort Study
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DOI：
10.1016/j.jamda.2022.01.053
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发表时间：
2022-07-01
影响因子：
7.6
通讯作者：
Nakamura, Kazutoshi
中科院分区：
文献类型：
--
作者：
Kitamura, Kaori;Watanabe, Yumi;Nakamura, Kazutoshi
目的：虽然晚年的体力活动（PA）被认为是痴呆症的预防因素，但不同类型的PA对老年早期痴呆症发展的影响尚不清楚。本研究的目的是在8年的随访中确定休闲时间和非休闲时间PA对中老年人痴呆风险的影响。设计：前瞻性队列研究。设置和参与者：参与者为13，773名40-74岁的社区居民，他们在2011- 2013年完成了Murakami队列研究的基线自填问卷调查。方法：主要预测因素是休闲时间和非休闲时间（通勤，职业工作和家务）PA评估MET评分（MET小时/天）。结果是使用长期护理保险数据库确定的新发展的痴呆症。协变量包括人口统计学、生活方式、体型、疾病史和PA水平。使用考克斯比例风险模型计算风险比（HR）。结果：参与者的平均年龄为59.0（SD 9.3）岁。较高水平的休闲时间PA与较低的HR相关（调整P趋势
Objective: Although physical activity (PA) in late life is considered a preventive factor for dementia, effects of different types of PAs on the development of dementia in early old age are unclear. This study aimed to determine the effect of leisure-time and non-leisure-time PAs on dementia risk in middle-aged and older adults during an 8-year follow-up.Design: Prospective cohort study.Setting and Participants: Participants were 13,773 community-dwelling individuals aged 40-74 years who completed the baseline self-administered questionnaire survey of the Murakami cohort study in 2011-2013.Methods: Main predictors were leisure-time and non-leisure-time (commute, occupational work, and housework) PAs as assessed by MET score (MET-hour/d). The outcome was newly developed dementia determined using a long-term care insurance database. Covariates included demographics, lifestyle, body size, disease history, and PA level. Hazard ratios (HRs) were calculated using Cox proportional hazards models.Results: Mean age of participants was 59.0 (SD 9.3) years. Higher levels of leisure-time PA were associated with lower HRs (adjusted P for trend