The time course of perisaccadic receptive field shifts in the lateral intraparietal area of the monkey
The time course of perisaccadic receptive field shifts in the lateral intraparietal area of the monkey
复制标题
DOI：
10.1152/jn.00519.2002
复制
发表时间：
2003-03-01
影响因子：
2.5
通讯作者：
Goldberg, ME
中科院分区：
文献类型：
--
作者：
Kusunoki, M;Goldberg, ME
当在注视任务中进行研究时，猴子顶叶外侧区（LIP）的神经元在视网膜专题坐标中具有视觉感受野。然而，在眼跳周围的时期，这些感受野经常发生变化，因此，如果眼球运动将消失的刺激的空间位置带入感受野，那么感受野外短暂闪烁的刺激将驱动神经元。这相当于视网膜感受野的短暂变化。该过程使猴脑能够在眼跳之后以空间精确的方式处理刺激，即使刺激仅出现在眼跳之前。我们通过在眼跳之前、期间或之后闪烁 100 毫秒与任务无关的刺激来研究这种感受野转变的时间过程。刺激可能出现在由眼跳之前的注视定义的感受野（当前感受野）或由眼跳之后的注视定义的感受野（未来感受野）。我们记录了两只恒河猴三个半球唇部 48 个视觉反应神经元的活动。我们研究了当前感受野任务中的 45 个神经元，其中眼跳从感受野中消除了刺激。在这些神经元中，与注视期间的活动相比，当刺激出现在眼跳之前 250 毫秒或更短时间内时，29/45 (64%) 的神经元表现出明显的反应减弱。对于那些表现出显着衰减（通过 t 检验，P < 0.05）的细胞，平均响应衰减为 38%。我们在未来的感受野任务中研究了 39 个神经元，其中眼跳将最近消失的刺激的空间位置带入感受野。其中 32/39 (82%) 的人对未来感受野中 100 毫秒的刺激有显着反应，甚至在眼跳之前 400 毫秒。神经元永远不会对由扫视从感受野外的一点移动到感受野外的另一点的刺激做出反应。神经元不一定对通过扫视从感受野的一个部分移动到另一部分的刺激表现出任何扫视抑制。刺激闪现
Neurons in the lateral intraparietal area of the monkey (LIP) have visual receptive fields in retinotopic coordinates when studied in a fixation task. However, in the period immediately surrounding a saccade these receptive fields often shift, so that a briefly flashed stimulus outside the receptive field will drive the neurons if the eye movement will bring the spatial location of that vanished stimulus into the receptive field. This is equivalent to a transient shift of the retinal receptive field. The process enables the monkey brain to process a stimulus in a spatially accurate manner after a saccade, even though the stimulus appeared only before the saccade. We studied the time course of this receptive field shift by flashing a task-irrelevant stimulus for 100 ms before, during, or after a saccade. The stimulus could appear in receptive field as defined by the fixation before the saccade (the current receptive field) or the receptive field as defined by the fixation after the saccade (the future receptive field). We recorded the activity of 48 visually responsive neurons in LIP of three hemispheres of two rhesus monkeys. We studied 45 neurons in the current receptive field task, in which the saccade removed the stimulus from the receptive field. Of these neurons 29/45 (64%) showed a significant decrement of response when the stimulus appeared 250 ms or less before the saccade, as compared with their activity during fixation. The average response decrement was 38% for those cells showing a significant (P < 0.05 by t-test) decrement. We studied 39 neurons in the future receptive field task, in which the saccade brought the spatial location of a recently vanished stimulus into the receptive field. Of these 32/39 (82%) had a significant response to stimuli flashed for 100 ms in the future receptive field, even 400 ms before the saccade. Neurons never responded to stimuli moved by the saccade from a point outside the receptive field to another point outside the receptive field. Neurons did not necessarily show any saccadic suppression for stimuli moved from one part of the receptive field to another by the saccade. Stimuli flashed