The role of targeted therapy and immune therapy in the management of non-small cell lung cancer brain metastases.
The role of targeted therapy and immune therapy in the management of non-small cell lung cancer brain metastases.
复制标题
靶向治疗和免疫治疗在非小细胞肺癌脑转移治疗中的作用。
DOI：
10.3389/fonc.2023.1110440
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发表时间：
2023
影响因子：
4.7
通讯作者：
Yu, Jennifer S.
中科院分区：
文献类型：
--
作者：
Billena, Cole;Lobbous, Mina;Cordova, Christine A.;Peereboom, David;Torres-Trejo, Alejandro;Chan, Timothy;Murphy, Erin;Chao, Samuel T.;Suh, John;Yu, Jennifer S.
关键词：
脑转移是非小细胞肺癌患者发病率和死亡率的重要来源。从历史上看，由于传统化疗的渗透性差，手术和放射治疗对于维持中枢神经系统内的疾病控制是必不可少的。随着针对可操作的驱动突变的靶向治疗的出现，有可能控制有限和无症状的颅内疾病，并延迟局部治疗直到进展。在这篇综述文章中，从文献中总结了生物和免疫治疗的颅内反应率和临床结果，并对其进行了评价，以帮助临床决策并确定进一步研究的领域。未来的临床试验应该优先考虑以患者为中心的生活质量和神经认知测量作为主要结果，并根据突变标记状态、疾病负担和症状急性程度对患者进行特异性分层。
Brain metastases are a significant source of morbidity and mortality in patients with non-small cell lung cancer. Historically, surgery and radiation therapy have been essential to maintaining disease control within the central nervous system due to poorly penetrant conventional chemotherapy. With the advent of targeted therapy against actionable driver mutations, there is potential to control limited and asymptomatic intracranial disease and delay local therapy until progression. In this review paper, intracranial response rates and clinical outcomes to biological and immune therapies are summarized from the literature and appraised to assist clinical decision making and identify areas for further research. Future clinical trials ought to prioritize patient-centered quality of life and neurocognitive measures as major outcomes and specifically stratify patients based on mutational marker status, disease burden, and symptom acuity.
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DOI：
10.1056/nejmoa2005653
发表时间：
2020-08-27
期刊：
The New England journal of medicine
影响因子：
--
作者：
Drilon A;Oxnard GR;Tan DSW;Loong HHF;Johnson M;Gainor J;McCoach CE;Gautschi O;Besse B;Cho BC;Peled N;Weiss J;Kim YJ;Ohe Y;Nishio M;Park K;Patel J;Seto T;Sakamoto T;Rosen E;Shah MH;Barlesi F;Cassier PA;Bazhenova L;De Braud F;Garralda E;Velcheti V;Satouchi M;Ohashi K;Pennell NA;Reckamp KL;Dy GK;Wolf J;Solomon B;Falchook G;Ebata K;Nguyen M;Nair B;Zhu EY;Yang L;Huang X;Olek E;Rothenberg SM;Goto K;Subbiah V
通讯作者：
Subbiah V
影响因子：
5.4
作者：
Bauer, Todd M.;Shaw, Alice T.;Felip, Enriqueta
通讯作者：
Felip, Enriqueta
影响因子：
120.7
作者：
Aoyama, Hidefumi;Shirato, Hiroki;Kobashi, Gen
通讯作者：
Kobashi, Gen
影响因子：
2.9
作者：
Zhang Q;Zhang X;Yan H;Jiang B;Xu C;Yang J;Chen Z;Su J;Wu YL;Zhou Q
通讯作者：
Zhou Q
影响因子：
5.2
作者：
Cascetta P;Sforza V;Manzo A;Carillio G;Palumbo G;Esposito G;Montanino A;Costanzo R;Sandomenico C;De Cecio R;Piccirillo MC;La Manna C;Totaro G;Muto P;Picone C;Bianco R;Normanno N;Morabito A
通讯作者：
Morabito A