Synergy between asbestos and smoking on lung cancer risks
Synergy between asbestos and smoking on lung cancer risks
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DOI：
10.1097/00001648-199907000-00011
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发表时间：
1999-07-01
期刊：
影响因子：
5.4
通讯作者：
Piekarski, C
中科院分区：
文献类型：
--
作者：
Erren, TC;Jacobsen, M;Piekarski, C
我们检查了12项流行病学研究的数据，以获得石棉和吸烟对肺癌风险之间生物协同作用的定量证据。在每项研究中，与联合暴露于两种药物相关的效应估计值超过了其单独效应的总和。我们使用三个指标探讨了研究中协同效应强度的变化：吸烟和石棉的联合效应与单独效应之和的比值（S），相互作用引起的相对超额风险（RERI），以及相互作用引起的风险比例（AP）。所有研究的S加权平均值为1.64（95%置信区间= 1.33-2.03）。与这一平均S相关的可归因比例估计为33%，这表明暴露于石棉的吸烟者中有三分之一的癌症病例可归因于两种致癌物的协同作用，这与它们的单独作用和归因于其他（“背景”）因素的作用不同。
We have examined data from 12 epidemiologic studies for quantitative evidence of biologic synergy between asbestos and smoking on lung cancer risks. Estimates of the effect associated with joint exposure to the two agents exceeded the sum of their separate effects in each study. We explored the variations in the strength of the synergistic effect across the studies using three indices: the ratio of the combined effects to the sum of the separate effects of smoking and asbestos (S), the relative excess risk due to interaction (RERI), and the attributable proportion of risk due to interaction (AP). The weighted average of S across all studies was 1.64 (95% confidence interval = 1.33-2.03). The attributable proportion associated with this average S was estimated as 33%, that suggests that one third of cancer cases among smokers who were exposed to asbestos can be attributed to the synergistic behavior of the two carcinogens, as distinct from their separate effects and those attributable to other ("background") factors.