PORTAL HYPERTENSIVE GASTROPATHY IN PATIENTS WITH CIRRHOSIS
PORTAL HYPERTENSIVE GASTROPATHY IN PATIENTS WITH CIRRHOSIS
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DOI：
10.1016/0016-5085(92)90332-s
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发表时间：
1992-06-01
期刊：
影响因子：
29.4
通讯作者：
TANIKAWA, K
中科院分区：
文献类型：
--
作者：
IWAO, T;TOYONAGA, A;TANIKAWA, K
门脉高压性胃病是最近公认的肝硬化的重要并发症。本文对47例肝硬化患者的临床特点、肝门血流动力学和肝功能进行了研究。轻度胃病15例（32%），重度胃病17例（36%）。胃病的出现似乎与年龄、性别、肝硬化原因或胃食管静脉曲张的等级无关。然而，严重胃病与门静脉压力梯度升高（与对照组相比，P< 0.01；与轻度胃病相比，P< 0.01）、肝窦阻力增加（与对照组相比，P< 0.01；与轻度胃病相比，NS）和肝血流量减少（与对照组相比，P< 0.01；与轻度胃病相比，NS）相关。此外，严重胃病患者肝脏代谢活动受损，这是通过吲哚菁绿的内在清除率来评估的（与对照组相比，P< 0.01；与轻度胃病相比，NS）。这些观察结果可能对肝硬化和门脉高压性胃病患者具有重要的治疗意义。
Portal hypertensive gastropathy is a recently recognized important complication of cirrhosis. In the present study, the clinical features, portohepatic hemodynamics, and hepatic function were investigated in a series of 47 patients with cirrhosis. Mild gastropathy was found in 15 patients (32%) and severe gastropathy in 17 patients (36%). The presence of gastropathy seemed to be independent of age, sex, cause of cirrhosis, or grade of gastroesophageal varices. However, severe gastropathy was associated with an increase in portal venous pressure gradient (vs. control,P< 0.01; vs. mild gastropathy,P< 0.01), an increase in hepatic sinusoidal resistance (vs. control,P< 0.01; vs. mild gastropathy, NS), and a decrease in hepatic blood flow (vs. control,P< 0.01; vs. mild gastropathy, NS). In addition, patients with severe gastropathy had impaired metabolic activity of the liver, which was assessed by intrinsic clearance of indocyanine green (vs. control,P< 0.01; vs. mild gastropathy, NS). These observations may have important therapeutic implications in patients with cirrhosis and portal hypertensive gastropathy.