Comparison of Vascular Response After Sirolimus-Eluting Stent Implantation Between Patients With Unstable and Stable Angina Pectoris
Comparison of Vascular Response After Sirolimus-Eluting Stent Implantation Between Patients With Unstable and Stable Angina Pectoris
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DOI：
10.1016/j.jcmg.2008.03.012
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发表时间：
2008-07-01
影响因子：
14
通讯作者：
Akasaka, Takashi
中科院分区：
文献类型：
--
作者：
Kubo, Takashi;Imanishi, Toshio;Akasaka, Takashi
本研究的目的是比较西罗莫司洗脱支架（SES）植入后的病变形态与不稳定型心绞痛（UAP）和稳定型心绞痛（SAP）患者使用光学相干断层扫描（OCT）。背景冠状动脉支架植入术前后的病变形态已被提出作为临床结果的重要预测因素。方法对55例不稳定型心绞痛（UAP）患者（n = 24）和重症急性胰腺炎（SAP）患者（n = 31）行OCT检查，观察SES植入前后和术后9个月的病变形态。结果：SES植入前后斑块破裂（42%vs.3%，p < 0.001）、冠状动脉内血栓（67%vs.3%，p < 0.001）和冠状动脉内血栓（10%vs.3%，p < 0.001）的发生率明显高于对照组（P <0.05）。结论：OCT能提供更详细的冠状动脉血管壁的信息，具有良好的临床应用价值。
OBJECTIVES The aim of the present study was to compare lesion morphologies after sirolimuseluting stent (SES) implantation between patients with unstable angina pectoris (UAP) and stable angina pectoris (SAP) with the use of optical coherence tomography (OCT).BACKGROUND The lesion morphologies before and after coronary stenting have been proposed as important predictors of clinical outcome. The high resolution of OCT provides detailed information of coronary vessel wall.METHODS We enrolled 55 patients (UAP: n = 24, SAP: n = 31), and examined lesion morphologies by using OCT at pre- and post-SES implantation and 9 months' follow-up.RESULTS The incidence of plaque rupture (42% vs. 3%, p < 0.001), intracoronary thrombus (67% vs. 3%, p