Intrapleural administration of OK432 in cancer patients: Activation of nk cells and reduction of suppressor cells
Intrapleural administration of OK432 in cancer patients: Activation of nk cells and reduction of suppressor cells
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癌症患者胸腔内注射 OK432：激活 nk 细胞并减少抑制细胞
DOI：
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发表时间：
1983
影响因子：
6.4
通讯作者：
M. Micksche
中科院分区：
文献类型：
--
作者：
A. Uchida;M. Micksche
12例癌性胸腔积液患者于第0天单次胸腔内注射OK432，观察其效果。第7天观察OK432对NK细胞活性的影响。两例患者没有临床证据表明ipl治疗有益。OK432。在其他10例患者中，胸腔积液和/或积液中的肿瘤细胞在第7天减少或消失。未经治疗的患者胸腔积液中NK细胞活性明显低或不存在，这是由于附着的积液细胞能够抑制NK细胞活性的维持和干扰素诱导的NK细胞活性的增强。I.pl。注射OK432后，NK细胞活性增强，NK抑制细胞活性减弱。另一方面，血液NK细胞活性不受i.pl的影响。OK432。体外处理未经治疗的OK432患者的积液单核细胞，但不使用干扰素，增强NK细胞活性。此外，未经治疗的患者的贴壁积液细胞在体外OK432治疗后失去了NK抑制功能。这些结果表明，i.pl。OK432可使胸腔积液中NK细胞活性增强，NK抑制细胞活性降低，这可能与i.pl抗肿瘤活性有关。OK432。
Twelve patients with carcinomatous pleural effusions were treated with single intrapleural (i.pl.) administration of OK432 on day 0 and the effects of i.pl. OK432 on natural killer (NK) cell activity were followed on day 7. Two patients showed no clinical evidence of therapeutic benefit from i.pl. OK432. In the other 10 patients, pleural effusions and/or tumor cells in the effusions had decreased or disappeared by day 7. NK cell activity was markedly low or absent in pleural effusions of untreated patients due to the presence of adherent effusion cells capable of suppressing the maintenance and interferon‐induced augmentation of NK cell activity. I.pl. injection of OK432 resulted in enhancement of NK cell activity and abrogation of NK suppressor cell activity in the effusions. On the other hand, blood NK cell activity was not consistently altered by i.pl. OK432. In vitro treatment of effusion mononu‐clear cells from untreated patients with OK432, but not with interferon, augmented NK cell activity. In addition, adherent effusion cells of untreated patients lost their NK suppressor function following in vitro OK432 treatment. These results suggest that i.pl. administration of OK432 will result in augmentation of NK cell activity and reduction of NK suppressor cell activity in pleural effusions, which could be responsible for the antitumor activity of i.pl. OK432.
腹水卵巢癌肿瘤相关淋巴细胞对自然杀伤活性的抑制。
DOI：
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发表时间：
1981
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Allavena,P;Introna,M;Mangioni,C;Mantovani,A
通讯作者：
Mantovani,A