Prognostic significance of gene amplification of ACTN4 in stage I and II oral tongue cancer
Prognostic significance of gene amplification of ACTN4 in stage I and II oral tongue cancer
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DOI：
10.1016/j.ijom.2017.03.001
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发表时间：
2017-08-01
影响因子：
2.4
通讯作者：
Honda, K.
中科院分区：
文献类型：
--
作者：
Kakuya, T.;Mori, T.;Honda, K.
尽管通过部分舌切除术对早期口腔舌癌进行了完全切除，但经常观察到颈部淋巴结晚期转移。ACTN4（蛋白名称：辅肌动蛋白 - 4）的基因扩增与多种癌症的转移潜能密切相关。本项回顾性研究旨在证明ACTN4基因扩增作为I/II期口腔舌癌患者预后生物标志物的潜在有用性。根据肿瘤标志物预后研究报告建议（REMARK）指南，回顾性纳入了54例I/II期口腔舌癌患者。分别通过荧光原位杂交（FISH）和免疫组织化学（IHC）评估ACTN4的拷贝数和辅肌动蛋白 - 4的蛋白表达。ACTN4基因扩增患者的总生存时间明显短于无基因扩增的患者（P = 0.0010，对数秩检验）。ACTN4基因扩增是I/II期口腔舌癌患者死亡的一个重要独立危险因素（风险比6.08，95%置信区间1.66 - 22.27）。ACTN4基因扩增是口腔舌癌总生存的一个潜在预后生物标志物。
Despite complete resection of the early stage of oral tongue cancer by partial glossectomy, late cervical lymph node metastasis is frequently observed. Gene amplification of ACTN4 (protein name: actinin-4) is closely associated with the metastatic potential of various cancers. This retrospective study was performed to demonstrate the potential usefulness of ACTN4 gene amplification as a prognostic biomarker in patients with stage I/II oral tongue cancer. Fifty-four patients with stage I/II oral tongue cancer were enrolled retrospectively, in accordance with the reporting recommendations for tumour marker prognostic studies (REMARK). guidelines. The copy number of ACTN4 and the protein expression of actinin-4 were evaluated by fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC), respectively. The overall survival time of patients with gene amplification of ACTN4 was significantly shorter than that of patients without gene amplification (P = 0.0010, log-rank test). Gene amplification of ACTN4 was a significant independent risk factor for death in patients with stage I/II oral tongue cancer (hazard ratio 6.08, 95% confidence interval 1.66-22.27). Gene amplification of AETN4 is a potential prognostic biomarker for overall survival in oral tongue cancer.