Marking 100 years since Rudolf Höber’s discovery of the insulating envelope surrounding cells and of the β-dispersion exhibited by tissue
Marking 100 years since Rudolf Höber’s discovery of the insulating envelope surrounding cells and of the β-dispersion exhibited by tissue
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纪念 Rudolf Höber 发现细胞周围的绝缘包膜和组织显示的 β 色散 100 周年
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
I. Schmueser
中科院分区：
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作者：
R. Pethig;I. Schmueser
1910年至1913年间，鲁道夫·赫伯提出了证据，证明红细胞和肌肉细胞的内部含有导电电解质，并且每个导电核心都包含在绝缘膜中。他通过一系列出色的电学实验证明，在低频（~150 Hz）下压实细胞样品的电导率比在~5 MHz下获得的值小约10倍。在穿孔的膜，低频电导率增加到一个值接近表现出在MHz频率。除了代表细胞生物学和电生理学发展的一个重要里程碑，赫伯的工作是我们现在所说的细胞悬浮液和新鲜组织所表现出的介电β分散的第一个描述。
Abstract Between 1910 and 1913 Rudolf Höber presented proof that the interiors of red blood cells and muscle cells contain conducting electrolytes, and that each conducting core is contained within an insulating membrane. He did this by demonstrating, in a series of remarkable electrical experiments, that the conductivity of compacted cell samples at low frequencies (~150 Hz) was about ten-times less than the value obtained at ~5 MHz. On perforation of the membrane, the low-frequency conductivity increased to a value approaching that exhibited at MHz frequencies. Apart from representing a major milestone in the development of cell biology and electrophysiology, Höber’s work was the first description of what we now call the dielectric β-dispersion exhibited by cell suspensions and fresh tissue.