Feeding condition and the relative contribution of different dopamine receptor subtypes to the discriminative stimulus effects of cocaine in rats.
Feeding condition and the relative contribution of different dopamine receptor subtypes to the discriminative stimulus effects of cocaine in rats.
复制标题
不同多巴胺受体亚型对可卡因在大鼠中的歧视性刺激作用的相对贡献。
DOI：
10.1007/s00213-013-3271-x
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发表时间：
2014-02
影响因子：
3.4
通讯作者：
France, Charles P.
中科院分区：
文献类型：
--
作者：
Baladi, Michelle G.;Newman, Amy H.;France, Charles P.
The contribution of dopamine receptor subtypes in mediating the discriminative stimulus effects of cocaine is not fully established. Many drug discrimination studies use food to maintain responding, necessitating food restriction, which can alter drug effects. This study established stimulus control with cocaine (10 mg/kg) in free-feeding and food-restricted rats responding under a schedule of stimulus shock termination (SST) and in food-restricted rats responding under a schedule of food presentation to examine whether feeding condition or the reinforcer used to maintain responding impacts the effects of cocaine. Dopamine receptor agonists and antagonists were examined for their ability to mimic or attenuate, respectively, the effects of cocaine. Apomorphine, quinpirole, and lisuride occasioned >90% responding on the cocaine-associated lever in free-feeding rats responding under a schedule of SST; apomorphine, but not quinpirole or lisuride, occasioned >90% responding on the cocaine lever in food-restricted rats responding under a schedule of SST. In food-restricted rats responding for food these drugs occasioned little cocaine lever responding and were comparatively more potent in decreasing responding. In free-feeding rats, the effects of cocaine were attenuated by the D2/D3 receptor antagonist raclopride and the D3 receptor-selective antagonist PG01037. In food-restricted rats, raclopride and the D2 receptor-selective antagonist L-741,626 attenuated the effects of cocaine. Raclopride antagonized quinpirole in all groups while PG01037 antagonized quinpirole only in free-feeding rats. These results demonstrate significant differences in the discriminative stimulus of cocaine that are due to feeding conditions and not to the use of different reinforcers across procedures.
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影响因子：
3.4
作者：
Filip, M;Bubar, MJ;Cunningham, KA
通讯作者：
Cunningham, KA
DOI：
10.1124/jpet.110.167619
发表时间：
2010-08-10
影响因子：
3.5
作者：
Achat-Mendes, Cindy;Grundt, Peter;Spealman, Roger D.
通讯作者：
Spealman, Roger D.
影响因子：
3.6
作者：
Christian, AJ;Goodwin, AK;Baker, LE
通讯作者：
Baker, LE
影响因子：
3.4
作者：
Costanza, RM;Barber, DJ;Terry, P
通讯作者：
Terry, P
影响因子：
2.7
作者：
Grundt, Peter;Husband, Sarah Little Jane;Newman, Amy Hauck
通讯作者：
Newman, Amy Hauck