THE PURINE PATH TO CHEMOTHERAPY

THE PURINE PATH TO CHEMOTHERAPY
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DOI:
10.1126/science.2649979
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发表时间:
1989-04-07
期刊:
影响因子:
56.9
通讯作者:
ELION, GB
ELION, GB
中科院分区:
综合性期刊1区
文献类型:
--
作者:
ELION, GB

文献摘要

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嘌呤代谢的抗代谢药物已被用作抗白血病、抗原虫和抗病毒药物,用于免疫抑制和移植,以及痛风和高尿酸血症。对它们的作用机制进行了综述。
Antimetabolites of purine metabolism have found a use as anti-leukaemic, antiprotozoal and antiviral drugs, in immunosuppression and transplantation, and in gout and hyperuricemia. Their mechanisms of action are reviewed.