Functional brain mapping of the macaque related to spatial working memory as revealed by PET
Functional brain mapping of the macaque related to spatial working memory as revealed by PET
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DOI：
10.1093/cercor/bhg109
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发表时间：
2004-01-01
期刊：
影响因子：
3.7
通讯作者：
Tsukada, H
中科院分区：
文献类型：
--
作者：
Inoue, M;Mikami, A;Tsukada, H
为了确定在非人灵长类动物的空间工作记忆的皮层区域，我们测量了局部脑血流量（rCBF）与[O-15]H2O和正电子发射断层扫描，而猴子进行视觉引导扫视（VGS）任务和眼动延迟反应（ODR）任务。统计参数图和基于感兴趣区域的分析均显示，主沟（PS）周围区域、上级凸面、弓形沟（AS）前堤、外侧眶额皮质（IOFC）、额极（FP）、前扣带回皮质（ACC）、顶内沟外侧堤（IIPS）和纹状体前皮质的rCBF增加。在前额叶皮层（PS、上级凸面、AS、IOFC和FP）中，rCBF值与ODR任务绩效得分呈正相关。从海马，rCBF值与ODR任务表现呈负相关。从AS、上级凸度、IOFC、FP、ACC和IIPS来看，PS的rCBF值与rCBF值呈正相关，与海马rCBF值呈负相关。这些结果表明，在前额叶皮层的神经回路直接贡献的空间工作记忆过程，在空间工作记忆过程中，后顶叶皮层和海马有不同的前额叶皮层的作用。
To define the cortical areas that subserve spatial working memory in a nonhuman primate, we measured regional cerebral blood flow (rCBF) with [O-15]H2O and positron emission tomography while monkeys performed a visually guided saccade (VGS) task and an oculomotor delayed-response (ODR) task. Both Statistical Parametric Mapping and regions of interest-based analyses revealed an increase of rCBF in the area surrounding the principal sulcus (PS), the superior convexity, the anterior bank of the arcuate sulcus (AS), the lateral orbitofrontal cortex (lOFC), the frontal pole (FP), the anterior cingulate cortex (ACC), the lateral bank of the intraparietal sulcus (lIPS) and the prestriate cortex. In the prefrontal cortex (PS, superior convexity, AS, lOFC and FP), rCBF values correlated positively with ODR task performance scores. From the hippocampus, rCBF values correlated negatively with ODR task performance. From the AS, superior convexity, lOFC, FP, ACC and lIPS, rCBF values of the PS correlated positively with rCBF values and negatively with hippocampus rCBF values. These results suggest that neural circuitry in the prefrontal cortex directly contributes the spatial working memory processes and that, in spatial working memory processes, the posterior parietal cortex and hippocampus have a different role to the prefrontal cortex.