Human immunodeficiency virus-associated lymphomas in the antiretroviral therapy era: Analysis of the National Cancer Data Base
Human immunodeficiency virus-associated lymphomas in the antiretroviral therapy era: Analysis of the National Cancer Data Base
复制标题
DOI：
10.1002/cncr.30112
复制
发表时间：
2016-09-01
期刊：
影响因子：
6.2
通讯作者：
Castillo, Jorge J.
中科院分区：
文献类型：
--
作者：
Olszewski, Adam J.;Fallah, Jaleh;Castillo, Jorge J.
抗病毒治疗改变了人类免疫缺陷病毒（HIV）相关非霍奇金淋巴瘤（NHL）患者的预后，但社区中淋巴瘤导向治疗的模式尚不清楚。方法作者分析了2004年至2012年10，769例诊断为HIV相关淋巴瘤患者的国家癌症数据库记录。评价了临床特征和化疗输送随时间的变化。使用多变量logistic回归研究了与未接受化疗相关的因素，报告了比值比（OR）和95%置信区间（CI）。
BACKGROUNDAntiviral therapy has altered the prognosis of patients with human immunodeficiency virus (HIV)-associated non-Hodgkin lymphoma (NHL), but patterns of lymphoma-directed therapy in the community are unknown.METHODSThe authors analyzed the National Cancer Data Base records of 10,769 patients who were diagnosed with HIV-associated lymphoma from 2004 through 2012. Changes in clinical characteristics and chemotherapy delivery over time were evaluated. Factors that were associated with not receiving chemotherapy were studied using multivariable logistic regression, reporting odds ratios (ORs) with 95% confidence intervals (CIs).RESULTSThe proportion of black or Hispanic patients with HIV-associated NHL increased from 41% in 2004 to 55% in 2012 (P