Genome scan among Nigerians linking blood pressure to chromosomes 2, 3, and 19
Genome scan among Nigerians linking blood pressure to chromosomes 2, 3, and 19
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DOI：
10.1161/01.hyp.0000035708.02789.39
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发表时间：
2002-11-01
期刊：
影响因子：
8.3
通讯作者：
Ward, R
中科院分区：
文献类型：
--
作者：
Cooper, RS;Luke, A;Ward, R
了解遗传对高血压的影响将有助于揭示这种复杂疾病的病理生理学，并提高我们对因果机制的理解。现代技术使得有可能检查足够的遗传标记，以支持在整个基因组中对候选区域的广义搜索。在本研究中，从尼日利亚西南部招募了一个家庭集，并在196个家庭的792个个体上对378个微卫星标记进行了分型。多点方差成分分析确定了连锁信号（比值对数[LOD]>1.74，P
An understanding of the genetic influences on hypertension would help unravel the pathophysiology of this complex disorder and improve our understanding of causal mechanisms. Contemporary technology makes it possible to examine enough genetic markers to support a generalized search across the entire genome for candidate regions. In the present study, a family set was recruited from southwest Nigeria, and 378 microsatellite markers were typed on 792 individuals in 196 families. Multipoint variance component analysis identified linkage signals (logarithm of the odds [LOD]>1.74, P