Training-induced recovery of visual motion perception after extrastriate cortical damage in the adult cat
Training-induced recovery of visual motion perception after extrastriate cortical damage in the adult cat
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DOI：
10.1093/cercor/bhg106
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发表时间：
2004-01-01
期刊：
影响因子：
3.7
通讯作者：
Pasternak, T
中科院分区：
文献类型：
--
作者：
Huxlin, KR;Pasternak, T
单侧伊博tenic酸损伤严重损害了猫对视半球整合局部运动信号（以方向范围阈值衡量）和从噪声中提取运动信号（以运动信号阈值衡量）的能力。这些缺陷在病变几个月后才被发现，并且仅限于用随机点刺激测量的阈值，而区分正弦波光栅运动方向的对比灵敏度不受影响。我们的目的是确定复杂运动知觉的缺陷是否可以恢复，以及恢复是自发的还是需要再训练。在每只猫中，在受损的视觉半球中选择一个单一的位置进行视觉再训练，这要求动物使用随机点刺激来区分运动方向，其中点的方向范围是不同的。15到40天的强化再训练使运动整合逐渐完全恢复。这种恢复是刺激特异性的，因为它不会从方向范围转移到运动信号阈值，而且它在很大程度上局限于再训练的视野位置。推迟几天到几个月再训练对恢复的程度或速度没有显著影响。一旦恢复，业绩在几个月内保持稳定。这些结果表明，层外视觉皮层损伤后复杂视觉运动知觉的恢复是一个活跃的过程，需要广泛的、刺激和视网膜特异性的视觉再训练。
Unilateral ibotenic acid lesions of the lateral suprasylvian (LS) cortex severely impair the ability of cats to integrate local motion signals (measured as direction range thresholds) and to extract motion signals from noise (measured as motion signal thresholds) in their contra-lesional visual hemifields. These deficits were found up to several months after the lesions and were limited to thresholds measured with random-dot stimuli, while contrast sensitivity for discriminating the direction of motion of sine-wave gratings remained unaffected. Our goal was to determine whether deficits of complex motion perception could recover and whether the recovery was spontaneous or required retraining. In each cat, a single location in the impaired visual hemifield was selected for visual retraining, which required the animals to discriminate motion direction using random-dot stimuli in which the range of dot directions was varied. Fifteen to 40 days of intensive retraining led to a gradual, complete recovery of motion integration. The recovery was stimulus specific since it did not transfer from direction range to motion signal thresholds, and it was largely restricted to the visual field locations retrained. Delaying the onset of retraining by several days to several months had no significant impact on the extent or rate of recovery. Once recovery was achieved, performance remained stable over a period of several months. These results suggest that recovery of complex visual motion perception after lesions of extrastriate visual cortex is an active process that requires extensive, stimulus- and retinotopically-specific visual retraining.