Basic Concepts and Methods for Joint Models of Longitudinal and Survival Data
Basic Concepts and Methods for Joint Models of Longitudinal and Survival Data
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DOI：
10.1200/jco.2009.25.0654
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发表时间：
2010-06-01
影响因子：
45.3
通讯作者：
Chen, Liddy M.
中科院分区：
文献类型：
--
作者：
Ibrahim, Joseph G.;Chu, Haitao;Chen, Liddy M.
纵向和生存数据的联合模型与许多癌症临床试验和观察性研究特别相关，其中纵向生物标志物（例如，循环肿瘤细胞，对疫苗的免疫反应和生活质量测量）可能与事件发生时间高度相关，例如无复发生存期或总生存期。在这篇文章中，我们给出了一个介绍性的概述联合建模，并提出了一个广泛的问题，在设计和分析的临床试验中使用联合模型的一般性讨论。为了证明我们的观点，我们提出了来自东部肿瘤协作组试验E1193的分析，并通过模拟研究检查了关节模型的一些操作特征。J Clin Oncol 28：2796-2801. (C)2010年美国临床肿瘤学会
Joint models for longitudinal and survival data are particularly relevant to many cancer clinical trials and observational studies in which longitudinal biomarkers (eg, circulating tumor cells, immune response to a vaccine, and quality-of-life measurements) may be highly associated with time to event, such as relapse-free survival or overall survival. In this article, we give an introductory overview on joint modeling and present a general discussion of a broad range of issues that arise in the design and analysis of clinical trials using joint models. To demonstrate our points throughout, we present an analysis from the Eastern Cooperative Oncology Group trial E1193, as well as examine some operating characteristics of joint models through simulation studies. J Clin Oncol 28:2796-2801. (C) 2010 by American Society of Clinical Oncology