Odor cues during slow-wave sleep prompt declarative memory consolidation
Odor cues during slow-wave sleep prompt declarative memory consolidation
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DOI：
10.1126/science.1138581
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发表时间：
2007-03-09
期刊：
影响因子：
56.9
通讯作者：
Born, Jan
中科院分区：
文献类型：
--
作者：
Rasch, Bjoern;Buechel, Christian;Born, Jan
睡眠有助于巩固记忆。一个被广泛接受的模型假设，这是因为新编码的记忆在睡眠期间经历了秘密的重新激活。我们通过呈现一种在先前学习期间作为背景呈现的气味，在人类睡眠期间暗示了新的记忆，因此表明重新激活确实会导致睡眠期间记忆的巩固。在慢波睡眠(SWS)期间再次暴露在气味中可以改善对海马体依赖的陈述性记忆的保留，但不能改善对海马体非依赖的程序记忆的保留。在快速眼动、睡眠或清醒时，或在先前学习过程中忽略气味时，气味再暴露是无效的。与这些发现一致的是，功能性磁共振成像显示，在SWS期间，对气味重新暴露的反应显著激活了海马区。
Sleep facilitates memory consolidation. A widely held model assumes that this is because newly encoded memories undergo covert reactivation during sleep. We cued new memories in humans during sleep by presenting an odor that had been presented as context during prior learning, and so showed that reactivation indeed causes memory consolidation during sleep. Re-exposure to the odor during slow-wave sleep (SWS) improved the retention of hippocampus-dependent declarative memories but not of hippocampus-independent procedural memories. Odor re-exposure was ineffective during rapid eye movement sleep or wakefulness or when the odor had been omitted during prior learning. Concurring with these findings, functional magnetic resonance imaging revealed significant hippocampal activation in response to odor re-exposure during SWS.