High prevalence of hepatitis C virus infection in Airin district, Osaka, Japan : A hospital-based study of 1162 patients
High prevalence of hepatitis C virus infection in Airin district, Osaka, Japan : A hospital-based study of 1162 patients
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日本大阪爱林区丙型肝炎病毒感染率高：一项针对 1162 名患者的医院研究
DOI：
10.1111/j.1872-034x.2011.00834.x
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Kawada N
中科院分区：
文献类型：
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作者：
Yamaguchi Y;Enomoto M;Fujii H;Tamori A;Sakaguchi H;Tanigawa T;Watanabe K;Fujiwara Y;Arakawa T;Harihara S;Monna T;Kawada N
目的：位于大坂市西成区的爱林区被称为日本最大的贫民区，也是日本最大的日工集中地。我们进行了一项大型医院为基础的研究，以确定丙型肝炎病毒（HCV）感染的患病率在distriction.Methods：受试者是1162名男性（平均年龄，57 ± 9岁）之间的2005年4月至2008年3月入住大坂社会医学中心医院。 结果：218例（18.8%）患者中发现抗-HCV抗体，相比之下，只有24例（2.1%）患者有B型肝炎表面抗原。在122名因肝病入院的患者中，抗HCV抗体的患病率为59%，在1040名患有其他疾病的患者中，抗HCV抗体的患病率为14%。在927例丙氨酸转氨酶水平正常（≤40 IU/L）的患者中，128例（13.8%）有抗HCV抗体。 抗HCV抗体的患病率随年龄的增长而显著增加（P<0.001）。 218例抗HCV抗体患者中至少有33例（15%）承认有注射吸毒史。26例患者开始干扰素治疗（11例基因型1，14例基因型2，1例无法分类），但只有6例完成了预定方案。20例患者被诊断为肝细胞癌，但只有7例早期疾病，其中根治性治疗，如手术肝切除术或经皮消融，是indic.Conclusion：HCV感染的流行率在爱林区是非常高的，比日本一般人群。对患者进行教育和采取严格的行动反对非法使用毒品是防止丙型肝炎病毒感染从该地区传播所不可或缺的。
Aim:The Airin district, located in Nishinari‐ku, Osaka, is known as Japan's largest slum area, and has the largest concentration of day laborers in the country. We conducted a large hospital‐based study to determine the prevalence of hepatitis C virus (HCV) infection in the district.Methods:The subjects were 1162 men (mean age, 57 ± 9 years) admitted to the Osaka Socio‐Medical Center Hospital between April 2005 and March 2008. Their case records were retrospectively reviewed.Results:Anti‐HCV antibodies were found in 218 (18.8%) patients; in contrast, only 24 (2.1%) patients had hepatitis B surface antigen. The prevalence of anti‐HCV antibodies was 59% among the 122 patients admitted for liver diseases and 14% among the 1040 patients with other diseases. Among 927 patients with normal alanine aminotransferase levels (≤40 IU/L), 128 (13.8%) had anti‐HCV antibodies. The prevalence of anti‐HCV antibodies increased with age significantly (P< 0.001). At least 33 of the 218 (15%) patients with anti‐HCV antibodies admitted to having a history of injection drug use. Interferon therapy was initiated in 26 patients (11 with genotype 1, 14 with genotype 2 and one unclassifiable), but only six completed their scheduled regimens. Hepatocellular carcinoma was diagnosed in 20 patients, but only seven had early‐stage disease in which curative treatment, such as surgical hepatectomy or percutaneous ablation, was indicated.Conclusion:The prevalence of HCV infection in the Airin district is extremely higher than that in the Japanese general population. Patient education and strict action against illegal drug use are indispensable to prevent the spread of HCV infection from the district.