Viruses as triggers of autoimmunity: facts and fantasies.

Viruses as triggers of autoimmunity: facts and fantasies.
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DOI:
10.1016/s1369-5274(99)80069-1
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发表时间:
1999-08
影响因子:
5.4
通讯作者:
J. Whitton;Robert S. Fujinami
J. Whitton;Robert S. Fujinami
中科院分区:
生物学2区
文献类型:
--
作者:
J. Whitton;Robert S. Fujinami

文献摘要

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自身免疫已被认为是几种人类慢性炎症性疾病的病因,最近的动物研究表明病毒可以诱发自身免疫性疾病。这些研究证明了病毒如何误导免疫系统,在这里我们批判性地讨论类似现象可能导致人类疾病的证据。
Autoimmunity has been proposed as the cause of several human chronic inflammatory diseases, and recent animal studies show that viruses can induce autoimmune disease. These studies demonstrate how viruses might misdirect the immune system, and here we discuss critically the evidence that similar phenomena may lead to human disease.