The Akkermansia muciniphila is a gut microbiota signature in psoriasis
The Akkermansia muciniphila is a gut microbiota signature in psoriasis
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Akkermansia muciniphila 是牛皮癣的肠道微生物群特征。
DOI：
10.1111/exd.13463
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发表时间：
2018-02-01
影响因子：
3.6
通讯作者：
Peng, Cong
中科院分区：
文献类型：
--
作者：
Tan, LiRong;Zhao, Shuang;Peng, Cong
银屑病是一种免疫介导的慢性炎症性皮肤病。尽管其发病机制尚不完全清楚，但Th17细胞及其产生的细胞因子，如IL-17、IL-22和IL-23，在银屑病的发病机制中起着至关重要的作用。有证据表明，银屑病有一些共同的特征，包括免疫反应(由于Th17细胞)和炎性细胞因子谱，系统性疾病包括炎症性肠病(IBD)和肥胖。最近的研究表明，肠道微生物区系在宿主体内平衡和免疫反应中起着至关重要的作用，特别是在Th17细胞中，但肠道微生物区系在银屑病中的作用尚不清楚。为了研究肠道微生物区系与银屑病的关系，我们利用16S rDNA测序平台对银屑病患者的肠道微生物区系进行了分析，发现银屑病患者体内粘液阿克曼氏菌的丰度显著降低。粘液支原体被认为在IBD和肥胖的发病机制中具有重要作用，因此，作为健康状况指标的粘液支原体可能是银屑病以及IBD和肥胖症的关键节点。综上所述，我们的研究发现银屑病患者肠道微生物区系的特征和功能发生了显著变化，这为理解银屑病的发病机制提供了一个新的角度。
Psoriasis is an immune-mediated chronic inflammatory skin disease. Although its pathogenesis is not fully understood, Th17 cells and the cytokines they produce, such as IL-17, IL-22 and IL-23, play critical roles in the pathogenesis of psoriasis. Evidence has demonstrated that psoriasis has some common features, including immune responses (due to Th17 cells) and inflammatory cytokine profiles, with systematic diseases including inflammatory bowel diseases (IBDs) and obesity. Recently, studies have demonstrated that the gut microbiota plays a crucial role in host homoeostasis and immune response, particular in Th17 cells, but the role of the gut microbiota in psoriasis remains unclear. To study the relationship between gut microbiota and psoriasis, we analysed microbiota profiles in psoriasis using a 16S rDNA sequencing platform, and we found that the abundance of Akkermansia muciniphila was significantly reduced in patients with psoriasis. A.muciniphila is believed to have an important function in the pathogenesis of IBD and obesity; therefore, A.muciniphila, which is an indicator of health status, may be a key node for psoriasis as well as IBD and obesity. Taken together, our study identified that gut microbiota signature and function are significantly altered in the gut of patients with psoriasis, which provides a novel angle to understanding the pathogenesis of psoriasis.