Longitudinal study of weight, appetite, performance status, and inflammation in advanced gastrointestinal cancer
Longitudinal study of weight, appetite, performance status, and inflammation in advanced gastrointestinal cancer
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DOI：
10.1207/s15327914nc352_5
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发表时间：
1999-01-01
影响因子：
2.9
通讯作者：
McArdle, CS
中科院分区：
文献类型：
--
作者：
O'Gorman, P;McMillan, DC;McArdle, CS
越来越多的证据表明，在大多数晚期癌症患者中，体重减轻与炎症反应有关。为了研究体重减轻、食欲、运动状态和炎症反应之间的时间关系，我们对50例体重减轻的晚期胃肠癌患者进行了为期6周的观察。根据患者体重是否减轻（3%,n = 16）、体重是否稳定（3%,n = 9）进行分组。与基线相比，随后体重减轻的组白蛋白浓度较低，c反应蛋白浓度较高（p < 0.05）。随访时，减肥组c反应蛋白浓度升高，肱三头肌皮褶厚度和Karnofsky运动性能下降（p < 0.05）。增重组的Karnofsky生产性能改善（p < 0.05）。试验6 ~ 8周时，两组三头肌皮褶厚度变化（p < 0.05）和Karnofsky性能状态（p < 0.01）差异有统计学意义。这些结果表明，在6至8周的时间内，体重减轻或增加>2.5 kg才能对胃肠道癌症减肥患者的运动状态产生显著的改变。此外，研究结果表明，炎症反应的存在与进一步的体重减轻和运动状态的恶化有关。
There is increasing evidence that, in most patients with advanced cancer, weight loss is associated with an inflammatory response. To examine the temporal relationship between weight loss, appetite, performance status, and the inflammatory response, 50 patients with advanced gastrointestinal cancer with weight loss were observed for six weeks. Patients were grouped according to whether they had lost weight (>3%, n = 16), were weighs stable (3%, n = 9). Ar baseline, the group that subsequently lost weight had lower albumin and higher C-reactive protein concentrations (p < 0.05). On follow-up, there was an increase in C-reactive protein concentration and reductions in triceps skinfold thickness and Karnofsky performance status in the weight-losing group (p < 0.05). In contrast Karnofsky performance status was improved in the group that gained weight (p < 0.05). Over the six to eight weeks, there was a difference in the changes of triceps skinfold thickness (p < 0.05) and Karnofsky performance status (p < 0.01) between the two groups. These results suggest that loss or gain of >2.5 kg over a six- to eight-week period is required to produce a significant alteration in performance status in weight-losing patients with gastrointestinal cancer. Moreover, the results suggest that the presence of an inflammatory response is associated with further weight loss and the deterioration of performance status.