Mechanisms underlying the increase in force and Ca2+ transient that follow stretch of cardiac muscle -: A possible explanation of the Anrep effect
Mechanisms underlying the increase in force and Ca2+ transient that follow stretch of cardiac muscle -: A possible explanation of the Anrep effect
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DOI：
10.1161/01.res.85.8.716
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发表时间：
1999-10-15
影响因子：
20.1
通讯作者：
Cingolani, HE
中科院分区：
文献类型：
--
作者：
Alvarez, BV;Pérez, NG;Cingolani, HE
心肌牵张产生的发展力（DF）增加，发生在两个阶段：第一阶段（快速发生）通常归因于肌丝钙反应性的增加，第二阶段（逐渐发展）归因于[Ca2 +]（i）的增加。将大鼠心室肌小梁从L-max的约88%拉伸至约98%，并分析第二力相。分别用BCECIF-AM、SBFI-AM和fura-2通过落射荧光测量细胞内pH、[Na +]（i）和Ca2+瞬变。牵张后DF增加1.94 ± 0.2 g/mm（2）（P
Myocardial stretch produces an increase in developed force (DF) that occurs in two phases: the first (rapidly occurring) is generally attributed to an increase in myofilament calcium responsiveness and the second (gradually developing) to an increase in [Ca2+](i). Rat ventricular trabeculae were stretched from approximate to 88% to approximate to 98% of L-max, and the second force phase was analyzed. Intracellular pH, [Na+](i), and Ca2+ transients were measured by epifluorescence with BCECIF-AM, SBFI-AM, and fura-2, respectively. After stretch, DF increased by 1.94+/-0.2 g/mm(2) (P