Orexin receptors in GtoPdb v.2021.3.
Orexin receptors in GtoPdb v.2021.3.
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DOI：
10.2218/gtopdb/f51/2021.3
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Winrow CJ
中科院分区：
文献类型：
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作者：
Coleman P;de Lecea L;Gotter A;Hagan J;Hoyer D;Kilduff T;Kukkonen JP;Porter R;Renger J;Siegel JM;Sutcliffe G;Upton N;Winrow CJ
食欲素受体(NCIUPHAR小组委员会关于食欲素受体的命名[])是由一个共同的前体，即原食欲素或食欲素前体，通过蛋白水解性切割和一些典型的多肽修饰而产生的内源性多肽，即食欲素-A和食欲素-B(也称为下丘脑-1和-2；33和28aa)激活的。目前临床上使用的增食欲素受体配体只有Suvorexant和Lemprexant，它们被用作催眠药。食欲素受体的晶体结构已被解决。
Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors []) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor, preproorexin or orexin precursor, by proteolytic cleavage and some typical peptide modifications. Currently the only orexin receptor ligands in clinical use are suvorexant and lemborexant, which are used as hypnotics. Orexin receptor crystal structures have been solved.