Unirhinal olfactory identification deficits in young male patients with schizophrenia and related disorders: association with impaired memory function
Unirhinal olfactory identification deficits in young male patients with schizophrenia and related disorders: association with impaired memory function
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DOI：
10.1016/s0920-9964(01)00227-4
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发表时间：
2002-08-01
影响因子：
4.5
通讯作者：
Kopala, LC
中科院分区：
文献类型：
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作者：
Good, KP;Martzke, JS;Kopala, LC
我们观察到患有精神障碍的男性患者中有单纯性嗅觉识别缺陷(小嗅觉障碍)的谨慎分组。这项研究的目的是检查左或右鼻孔微史密斯与文字神经心理测试的表现之间的关系，该测试对精神分裂症发病机制中涉及的大脑区域的病变敏感。66名被诊断为精神分裂症或相关疾病的男性患者接受了一系列神经心理测试，这些测试对文字和区域(颞叶和额叶)功能障碍敏感。宾夕法尼亚大学的气味识别测试(UPSIT)被单鼻部接受，结果得分被用来将患者分为嗅觉亚组。比较不同亚组之间的神经心理测试分数。采用混合设计Manova，将嗅觉状态为认知领域(右侧微小型；RM，n=8，左侧微小型；LM，n=20，正常精神分裂症对照组；NSzC，n=38)作为受试者之间的因素，而大脑半球(左侧与右侧)和领域(执行/流利性与记忆力)为受试者内因素。观察到三向(嗅觉亚群按半球和区域)交互作用。右侧和左侧小脑亚组均出现非言语记忆障碍。左侧鼻孔小肌症患者存在言语记忆障碍。这些结果表明，单眼嗅觉表现可能提供了一种有意义的方式来对精神分裂症患者进行分型。此外，数据表明，精神分裂症患者的嗅觉缺陷与颞叶功能障碍有关，而不是额叶异常。这些数据与将正确的颞叶完整性与适当的嗅觉处理联系起来的报告是一致的。(C)2002 Elsevier Science B.V.保留所有权利。
We have observed discreet subgroups of male patients with psychotic disorders who have unirhinal olfactory identification deficits (microsmia). The purpose of this study was to examine the relationship between left or right nostril microsmia and performance on literalised neuropsychological tests sensitive to lesions in brain areas implicated in the pathogenesis of schizophrenia. Sixty-six male patients diagnosed with schizophrenia or related disorders were assessed with a battery of neuropsychological tests, sensitive to literalised and regional (temporal and frontal lobe) dysfunction. The University of Pennsylvania Smell Identification Test (UPSIT) was administered unirhinally and resultant scores were used to classify patients into olfactory subgroups. Neuropsychological test scores were compared amongst subgroups. A mixed design MANOVA was performed on cognitive domains with olfactory status (right microsmic; RM, n = 8, left microsmic; LM, n = 20, and normosmic schizophrenic controls; NSzC, n = 38) as the between subject factor while hemisphere (left versus right) and domain (executive/fluency versus memory) were within-subject factors. A three-way (olfactory subgroup by hemisphere by region) interaction was observed. Non-verbal memory impairment was observed in the right and left microsmic subgroups. Verbal memory deficits were demonstrated in patients with left nostril microsmia. These results indicate that unirhinal olfactory performance may provide a meaningful manner by which to subtype patients with schizophrenia. Moreover, the data suggest that olfactory deficits in patients with schizophrenia are associated with dysfunction of temporal lobe, rather than frontal lobe abnormalities. The data are consistent with reports linking the right temporal lobe integrity to adequate olfactory processing. (C) 2002 Elsevier Science B.V. All rights reserved.