Geography of intestinal permeability and absorption
Geography of intestinal permeability and absorption
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DOI：
10.1136/gut.44.4.483
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发表时间：
1999-04-01
期刊：
影响因子：
24.5
通讯作者：
Gregory, GG
中科院分区：
文献类型：
--
作者：
Menzies, IS;Zuckerman, MJ;Gregory, GG
背景-肠道形态和功能因地理位置而异。目的-这些功能在欧洲、北美、中东、亚洲、非洲和加勒比海国家的无症状志愿者中进行评估。方法-在禁食过夜后摄入100 ml含3-0-甲基-D-葡萄糖、D-木糖、L-鼠李糖和乳果糖的等渗试验溶液后，从每个受试者中采集5小时尿液，以评估主动（3-0-甲基-D-葡萄糖）和被动（D-木糖）载体介导的和非介导的（L-鼠李糖）吸收能力，以及肠渗透性（乳果糖：鼠李糖比率）。结果-来自热带国家的受试者（n=218）与居住在温带和亚热带地区（欧洲、美国、卡塔尔）的受试者（n=224）的结果比较显示出显著差异。热带地区的居民平均乳果糖：鼠李糖比率较高，3-0-甲基-D-葡萄糖、D-木糖和L-鼠李糖的平均5小时回收率较低，表明肠道通透性较高，吸收能力较低。对来访居民的调查表明，肠道通透性和吸收能力的差异与居住地区有关。受试者从得克萨斯州和卡塔尔，虽然由几个民族和居民在亚热带地区，没有表现出显着差异，从欧洲subjects. Conclusions-有明确划分的变化，肠道通透性和吸收能力影响无症状的居民不同的地理区域对应的条件描述为热带肠病。结果表明环境因素的重要性。所调查的参数可能与土著居民和旅行者易患腹泻病和营养不良有关。来自热带地区的患者的肠功能可能难以解释，但应考虑到在无症状正常人群中发现的数值范围。
Background-Intestinal morphology and function vary geographically.Aims-These functions were assessed in asymptomatic volunteers in European, North American, Middle Eastern, Asian, African, and Caribbean countries.Methods-Five hour urine collections were obtained from each subject following ingestion of a 100 ml iso-osmolar test solution containing 3-0-methyl-D-glucose, D-xylose, L-rhamnose, and lactulose after an overnight fast, to assess active (3-0-methyl-D-glucose) and passive (D-xylose) carrier mediated, and non-mediated (L-rhamnose) absorption capacity, as well as intestinal permeability (lactulose:rhamnose ratio).Results-A comparison of results for subjects from tropical countries (n=218) with those resident in the combined temperate and subtropical region (Europe, United States, Qatar) (n=224) showed significant differences. Residents in tropical areas had a higher mean lactulose:rhamnose ratio and lower mean five hour recoveries of 3-0-methyl-D-glucose, D-xylose, and L-rhamnose, indicating higher intestinal permeability and lower absorptive capacity. Investigation of visiting residents suggested that differences in intestinal permeability and absorptive capacity were related to the area of residence. Subjects from Texas and Qatar, although comprised of several ethnic groups and resident in a subtropical area, showed no significant difference from European subjects.Conclusions-There are clearly demarcated variations in intestinal permeability and absorptive capacity affecting asymptomatic residents of different geographical areas which correspond with the condition described as tropical enteropathy. Results suggest the importance of environmental factors. The parameters investigated may be relevant to the predisposition of the indigenous population and travellers to diarrhoeal illness and malnutrition. Intestinal function in patients from the tropics may be difficult to interpret, but should take into account the range of values found in the asymptomatic normal population.