Intestinal alkaline phosphatase: a summary of its role in clinical disease.
Intestinal alkaline phosphatase: a summary of its role in clinical disease.
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DOI：
10.1016/j.jss.2015.12.008
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发表时间：
2016-05-01
期刊：
影响因子：
--
通讯作者：
Gourlay DM
中科院分区：
文献类型：
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作者：
Fawley J;Gourlay DM
在过去的几年中，越来越多的证据表明肠道碱性磷酸酶 (IAP) 在减轻炎症介导的疾病方面具有新的作用。 IAP 是一种由肠上皮表达的内源性蛋白质，被认为在维持肠道稳态中发挥着至关重要的作用。 IAP 表达或功能的丧失与肠道炎症、菌群失调、细菌易位以及随后的全身炎症增加有关。由于这些事件是与外科医生相关的许多疾病的病理生理学的基石，我们试图回顾最近在动物和人类中关于 IAP 的生理功能、作用机制和特定外科疾病的研究。
Over the past few years, there is increasing evidence implicating a novel role for Intestinal Alkaline Phosphatase (IAP) in mitigating inflammatory mediated disorders. IAP is an endogenous protein expressed by the intestinal epithelium that is believed to play a vital role in maintaining gut homeostasis. Loss of IAP expression or function is associated with increased intestinal inflammation, dysbiosis, bacterial translocation and subsequently systemic inflammation. As these events are a cornerstone of the pathophysiology of many diseases relevant to surgeons, we sought to review recent research in both animal and humans on IAP’s physiologic function, mechanisms of action and current research in specific surgical diseases.