Endometrial serous carcinoma: its molecular characteristics and histology-specific treatment strategies.
Endometrial serous carcinoma: its molecular characteristics and histology-specific treatment strategies.
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DOI：
10.3390/cancers4030799
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发表时间：
2012-08-07
期刊：
影响因子：
5.2
通讯作者：
Miyazaki K
中科院分区：
文献类型：
--
作者：
Nakayama K;Nakayama N;Ishikawa M;Miyazaki K
子宫内膜癌是女性第四大常见恶性肿瘤，大多数病例被归类为早期子宫内膜样瘤，预后良好。然而，子宫内膜浆液性组织亚型(ESC)虽然只占所有子宫内膜癌的10%，但却导致了不成比例的死亡人数。与雌激素依赖、分化良好的子宫内膜样瘤不同，胚胎干细胞不依赖雌激素，往往出现在晚期和老年女性中，后者通常与发病年龄较小有关。ESC的治疗需要积极的手术和多模式的辅助治疗。在这篇综述中，我们描述了胚胎干细胞的临床行为、分子方面和治疗策略。
Endometrial cancer is the fourth most common malignancy in women, with most cases being classified as early stage endometrioid tumors that carry a favorable prognosis. The endometrial serous histological subtype (ESC), however, while only accounting for 10% of all endometrial cancers is responsible for a disproportionate number of deaths. Unlike the estrogen-dependent, well differentiated endometrioid tumors, which are commonly associated with a younger age of onset, ESCs are estrogen-independent and tend to present at an advanced stage and in older women. Treatment for ESC entails aggressive surgery and multimodal adjuvant therapy. In this review, we describe the clinical behavior, molecular aspects, and treatment strategies for ESC.