Man-to-woman sexual transmission of HIV: longitudinal study of 343 steady partners of infected men.
Man-to-woman sexual transmission of HIV: longitudinal study of 343 steady partners of infected men.
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DOI：
10.1097/00126334-199305000-00010
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发表时间：
1993-05
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通讯作者：
A. Saracco;M. Musicco;A. Nicolosi;G. Angarano;C. Arici;G. Gavazzeni;P. Costigliola;Sergio Gafà;C. Gervasoni;R. Luzzati;F. Piccinino;Francesco Puppo;B. Salassa;Ralessando Sinicco;R. Stellini;U. Tirelli;G. Turbessi;G. Vigevani;G. Visco;R. Zerboni;A. Lazzarin
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作者：
A. Saracco;M. Musicco;A. Nicolosi;G. Angarano;C. Arici;G. Gavazzeni;P. Costigliola;Sergio Gafà;C. Gervasoni;R. Luzzati;F. Piccinino;Francesco Puppo;B. Salassa;Ralessando Sinicco;R. Stellini;U. Tirelli;G. Turbessi;G. Vigevani;G. Visco;R. Zerboni;A. Lazzarin
为了研究异性性传播HIV感染的发病率和危险因素，我们随访了343名血清阴性女性，受感染男性的稳定的一夫一妻制伴侣，其获得HIV的唯一风险是与受感染伴侣发生性接触。在529.6人年（py）的观察中发生了19次血清转化，发病率为3.6/100 py。在不经常使用或从不使用避孕套的妇女中，发病率为7.2/100 py，而在经常使用避孕套的妇女中，发病率为1.1/100 py [相对危险度（RR）6.6，95%可信区间（CI）1.9-21.9]。肛交仅与那些不总是使用避孕套的女性的风险增加相关（RR 1.4，95%CI 0.4-4.8）。在22名使用口服避孕药的妇女中未观察到血清转换。其中一名使用宫内避孕器的妇女血清转化。在不总是使用避孕套的夫妇中，血清转化更频繁地发生在患有症状性疾病的男性的伴侣中，其CD 4+细胞数量较低（或≥ 1年）的男性患者血清转换的风险较低（RR 0.3，CI 0.1-0.8），而血清p24抗原阳性的男性患者其配偶血清转换的风险较高（RR = 4.0，CI 0.1-0.8）。
To study incidence and risk factors of heterosexually transmitted HIV infection, we followed a cohort of 343 seronegative women, stable, monogamous partners of infected men whose only risk of acquiring HIV was sexual exposure to the infected partner. Nineteen seroconversions occurred in 529.6 person years (py) of observation, yielding an incidence rate of 3.6 per 100 py. The incidence rate was 7.2 per 100 py among women who did not always use or never used condoms and 1.1 among those who always used them [relative risk (RR) 6.6, 95% confidence interval (CI) 1.9-21.9]. Anal sex was associated with a risk increase in only those women not always using condoms (RR 1.4, 95% CI 0.4-4.8). No seroconversions were observed among 22 women using oral contraceptives. One of the women using intrauterine devices seroconverted. In couples who did not always use condoms, seroconversions occurred more frequently in partners of men with symptomatic diseases, with a low CD4+ cell number ( or = 1 year) showed a lower risk of seroconversion (RR 0.3, CI 0.1-0.8), and those partners of men positive for p24 antigen in serum had an increased risk of seroconversion (RR = 4.0, CI 0.1-0.8).